March 2019

Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L.

Advanced glycation end-products (AGEs) have been shown to be implicated in many degenerative disorders as well as diabetic pathology. Of interest, several natural compounds including phenolic constituents are capable of inhibiting the formation of AGEs. Bio-guided fractionation of a methanol extract from Mangifera indica leaves led to the characterization of six antiglycative constituents including gallic acid (1),...

Author(s): Samba Fama Ndoye, Didier Fraisse, Blandine Akendengué, Rokhaya Sylla Gueye, Cheikh Sall, Mael Gainche, Insa Seck, Catherine Felgines, Matar Seck and François Senejoux