Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3627

Full Length Research Paper

Bio-guided identification of antiglycative constituents from the leaves of Mangifera indica L.

Samba Fama Ndoye
  • Samba Fama Ndoye
  • Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, PB 5005 Dakar-Fann, Sénégal.
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Didier Fraisse
  • Didier Fraisse
  • Université Clermont Auvergne, INRA, UNH, F-63000 Clermont-Ferrand, France.
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Blandine Akendengué
  • Blandine Akendengué
  • Department of Pharmacology and Toxicology, Faculty of Medicine and Health Sciences (USS). PB 4009 Libreville, Gabon.
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Rokhaya Sylla Gueye
  • Rokhaya Sylla Gueye
  • Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, PB 5005 Dakar-Fann, Sénégal.
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Cheikh Sall
  • Cheikh Sall
  • Laboratory of Chemistry, Training and Research Unit of Health, Thiès University, PB 967 Thiès, Sénégal.
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Mael Gainche
  • Mael Gainche
  • Université Clermont Auvergne, CNRS, SIGMA Clermont, ICCF, F-63000 Clermont-Ferrand, France.
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Insa Seck
  • Insa Seck
  • Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, PB 5005 Dakar-Fann, Sénégal.
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Catherine Felgines
  • Catherine Felgines
  • Université Clermont Auvergne, INRA, UNH, F-63000 Clermont-Ferrand, France.
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Matar Seck
  • Matar Seck
  • Laboratory of Organic and Therapeutic Chemistry, Faculty of Medicine, Pharmacy and Odontology, Cheikh Anta Diop University, PB 5005 Dakar-Fann, Sénégal.
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François Senejoux
  • François Senejoux
  • Université Clermont Auvergne, INRA, UNH, F-63000 Clermont-Ferrand, France.
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  •  Received: 10 January 2019
  •  Accepted: 18 February 2019
  •  Published: 25 March 2019

Abstract

Advanced glycation end-products (AGEs) have been shown to be implicated in many degenerative disorders as well as diabetic pathology. Of interest, several natural compounds including phenolic constituents are capable of inhibiting the formation of AGEs. Bio-guided fractionation of a methanol extract from Mangifera indica leaves led to the characterization of six antiglycative constituents including gallic acid (1), iriflophenone-3-C-β-D-glucoside (2), mangiferin (3), iriflophenone-3-C-(2'-O-galloyl)-β-D-glucoside (4), hyperoside (5) and isoquercitrin (6). With IC50 values lower than that of aminoguanidine, the six identified phenolic compounds can be regarded as remarkable inhibitors of advanced glycation end products formation and M. indica leaves should be considered as a potential nutraceutical resource to prevent carbonyl stress-related diseases.

Key words: Mangifera indica, antiglycation, radical scavenging, phenolics, benzophenone.