Journal of
Neuroscience and Behavioral Health

  • Abbreviation: J. Neurosci. Behav. Health
  • Language: English
  • ISSN: 2141-2286
  • DOI: 10.5897/JNBH
  • Start Year: 2009
  • Published Articles: 66

Full Length Research Paper

Acute low dose monosodium glutamate retards novelty induced behaviours in male swiss albino mice

Onaolapo, Olakunle James1* and Onaolapo, Adejoke Yetunde2
1Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University, Ogbomoso Oyo State, Nigeria. 2Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Ladoke Akintola University, Ogbomoso, Oyo State, Nigeria.
Email: [email protected]

  •  Accepted: 12 April 2011
  •  Published: 30 April 2011


The study investigated the effects of acute systemic administration of monosodium glutamate (MSG) on novelty induced behaviours in male albino mice. The aim was to provide information on the neurobehavioural effects of a single i.p.(intraperitoneal) injection of MSG. Forty male swiss albino mice (age, 6 to 8 weeks; mean weight, 22.5 ± 2.5 g) were divided into four treatment groups (n = 10). Novelty induced behaviours that is horizontal locomotion (line crossing), rearing and grooming was carried out after intraperitoneal injection of varying doses of MSG (0.5, 1.0 and 1.5 m/kg) or its vehicle (normal saline). Each parameter was measured over a thirty minute period of ten minute intervals. Statistical analysis was carried out using a one way ANOVA followed by the Student-Newman-Keul’s test. Compared with the control mice, a single intraperitoneal injection of MSG significantly reduced locomotor and rearing activities as horizontal locomotion and rearing was found to be significantly lower at 1.5 mg/kg when compared to their respective controls; grooming showed an initial slight increase followed by a visual but progressive reduction. The study concluded that acute administration of monosodium glutamate has a retardant effect on novelty induced behaviors in male mice.


Key wordsMonosodium glutamate, novelty induced behaviours.