April 2011

Multiple sclerosis: An overview of the disease and current concepts of its pathophysiology

The oligodendrocytes, myelin-producing cells in the central nervous system (CNS), have an essential role in “multiple sclerosis”. This disease is of unknown etiology, and thus, of a variable prognosis. The main pathologic feature is the injury to the myelin and loss of oligodendrocytes in the CNS. Studies of animal models, demonstrating that autoreactive T cells (CD4 or CD8) can result in inflammatory...

Author(s): Bolaños-Jiménez R., Arizmendi-Vargas J., Carrillo-Ruiz J. D., López-Lizárraga M. E., Calderón Álvarez-Tostado J. L., Martínez-Menchaca H., Leyva Resendiz I., Serrato-Ávila J. L., Rendón-Molina A. and Rivera-Silva G.

April 2011

Acute low dose monosodium glutamate retards novelty induced behaviours in male swiss albino mice

The study investigated the effects of acute systemic administration of monosodium glutamate (MSG) on novelty induced behaviours in male albino mice. The aim was to provide information on the neurobehavioural effects of a single i.p.(intraperitoneal) injection of MSG. Forty male swiss albino mice (age, 6 to 8 weeks; mean weight, 22.5 ± 2.5 g) were divided into four treatment groups (n = 10). Novelty induced...

Author(s): Onaolapo, Olakunle James and Onaolapo, Adejoke Yetunde