Introduction. The use of psychoactive drugs remains a public health and social issue in Benin and impacts health, medical and social life at working place. The study aims to determine the prevalence and the factors associated with psychoactive drugs use in 2019 in two companies based in Cotonou, Benin. Methods. A cross-sectional survey was carried out from 09 to 31 December 2019. The study involved 455 workers aged 22 to 60 in two companies, selected by using a stratified survey technique. Data were collected using a questionnaire providing the socio-demographic and occupational factors, individual characteristics and labor conditions of workers. Associated factors were determine by a univariate and multivariate analysis. Results. Alcohol was the substance most consumed with an abuse prevalence of 7.7% followed by tobacco with a prevalence of 5.5% and drugs at 4.6 % and finally cannabis at 1.3%. After adjusting for the other variables: sick leave decreased with alcohol consumption, OR=0.31 [0.10-0.95]; regular leave increased with alcohol consumption OR=16.90 [1.96-145.75]; and overinvestment decreased with alcohol consumption OR=0.33 [0.14-0.78]. Conclusion. The use of PAD is a public health problem in the workplace. Awareness-raising for workers and training actions towards medical staff are required in the workplace in other to improve working conditions and the reduce drugs consumption.

Keywords: Psychoactive drugs, workplace, alcohol, tobacco, drugs, Benin.