May 2016

Design and optimisation of novel Huperzine A analogues capable of modulating the acetylcholinesterase receptor for the management of Alzheimer’s disease

This is a de novo drug design study that aimed to create novel structures based on the alkaloid Huperzine A, capable of inhibiting the acetylcholinesterase (AChE) enzyme ligand binding pocket (AChE_LBP) for the management of Alzheimer’s disease. The X-ray crystallographic model of the Torpedo Californica AChE complexed to Huperzine A was identified from the Protein Data Bank (PDB ID 1VOT). Molecular visualisation...

Author(s): Sara Bonavia and Claire Shoemake

May 2016

Analysis of bioactive chemical compounds of Euphorbia lathyrus using gas chromatography-mass spectrometry and Fourier-transform infrared spectroscopy

The aim of this study was determination the phytochemical composition of methanolic seeds extract of Euphorbia lathyrus. Gas chromatography-mass spectrometry (GC-MS) analysis of E. lathyrus revealed the existence of the Carbonic acid, (ethyl)(1,2,4-triazol-1-ylmethyl) diester, 1H-Pyrrole,2,5-dihydro-1-nitroso, Hexanal dimethyl acetal,  Isosorbide dinitrate, DL-Arabinose,...

Author(s): Azhar Abduameer Sosa, Suhaila Husaein Bagi, and Imad Hadi Hameed