Journal of
Parasitology and Vector Biology

  • Abbreviation: J. Parasitol. Vector Biol.
  • Language: English
  • ISSN: 2141-2510
  • DOI: 10.5897/JPVB
  • Start Year: 2009
  • Published Articles: 179

Full Length Research Paper

Immunoglobulin evolution and associated factors with intestinal schistosomiasis after treatment in rural Burkina Faso

Nina Gouba
  • Nina Gouba
  • Université Nazi Boni, Unité de Formation et de Recherche en Sciences et Techniques UFR/ST, Bobo Dioulasso 01 BP 1091, Burkina Faso.
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Hermann Sorgho
  • Hermann Sorgho
  • Institut de Recherche en Sciences de la Santé Direction Régionale Centre Ouest, Nanoro, BP 218, Burkina Faso.
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Isidore Traoré
  • Isidore Traoré
  • Centre Muraz, Bobo-Dioulasso, Institut National de Santé Publique, Bobo-Dioulasso, 01 BP 390, Burkina Faso.
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Olivier O. Sombié
  • Olivier O. Sombié
  • Institut de Recherche en Sciences de la Santé, Direction Régionale de l’Ouest, Bobo Dioulasso, 01 BP 545, Burkina Faso.
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Yeri E. Hien
  • Yeri E. Hien
  • Université Joseph Ki-Zerbo, Unité de Formation et de Recherche en Science de la Vie et de la Terre (UFR/ ST), Laboratoire de Biochimie et d’Immunologie Appliquée (LaBIA) 03 B. P 7021 Ouagadougou, Burkina Faso.
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Nico F. W. Dena
  • Nico F. W. Dena
  • Université Nazi Boni, Unité de Formation et de Recherche en Sciences et Techniques UFR/ST, Bobo Dioulasso 01 BP 1091, Burkina Faso.
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Jean B. Ouédraogo
  • Jean B. Ouédraogo
  • Institut de Recherche en Sciences de la Santé, Direction Régionale de l’Ouest, Bobo Dioulasso, 01 BP 545, Burkina Faso.
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  •  Received: 10 October 2020
  •  Accepted: 02 December 2020
  •  Published: 31 December 2020

Abstract

The performance of specific antibodies in a post-chemotherapy situation remains a controversial issue. Thus the study aims to investigate the variations of different immunoglobulins, IgG, IgG subclasses, IgM and IgA against Schistosoma mansoni soluble eggs antigens post-treatment and their correlation with eggs excretion. A longitudinal study was conducted on 928 participants over 5 years of age from February 2007 to March 2008 in “Vallée du Kou” in Burkina Faso, a rural area where S. mansoni is endemic. At the inclusion and during follow-up visits (post 1.5, 3, 6 and 12 months), stools and blood samples were examined for Schistosome eggs obtained from stools  by the Kato-Katz test method and serum antibodies (IgM, IgA, IgG, IgG1, IgG2, IgG3, IgG4) obtained from blood by ELISA targeting the antigens of schistosome eggs. Subjects who were stool-egg-positive were treated with praziquantel in a single oral dose of 40 mg/kg. The overall prevalence of S. mansoni infection was 23.27% (216/928) with 77.32% (167/216) having a light intensity of infection. Factors associated with parasite eggs load were IgA, IgG1 and IgG4 titres. During each visit, each increase in IgA titre of 1 unit was associated with a significant reduction in parasite egg load of 50 eggs (p <0.002). The increase in IgG1 and IgG4 titres by 1 unit was associated with significant increases in the parasite egg count of 21 and 32, respectively. IgG1, IgG2 and IgG4 titres decreased significantly during the follow-up time (p<0.0001). In contrast, the titre of IgG3 increased significantly (p=<0.0001). This study showed that IgA, IgG1 and IgG4 are associated with decrease in parasite egg loads in stool and could be a good marker for treatment efficacy.

Key words: Immunoglobulins, Schistosoma mansoni, eggs, praziquantel, ELISA, kato-katz, Burkina Faso.