Journal of
Parasitology and Vector Biology

  • Abbreviation: J. Parasitol. Vector Biol.
  • Language: English
  • ISSN: 2141-2510
  • DOI: 10.5897/JPVB
  • Start Year: 2009
  • Published Articles: 202

Full Length Research Paper

Analysis of clinical and multi antigenic aspects of malaria serodiagnosis tests prescribed to patients at Institut Pasteur de Côte d'Ivoire from 2016 to 2019

Serge-Stéphane Yao
  • Serge-Stéphane Yao
  • Malariology Department, Institut Pasteur, Côte d’Ivoire.
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Sylvain Beourou
  • Sylvain Beourou
  • Malariology Department, Institut Pasteur, Côte d’Ivoire.
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Brice Kouakou Bla
  • Brice Kouakou Bla
  • UFR Biosciences, Félix Houphouët-Boigny University, Abidjan, Côte d'Ivoire.
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David Koffi
  • David Koffi
  • Malariology Department, Institut Pasteur, Côte d’Ivoire.
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N’guessan Landry Tiacoh
  • N’guessan Landry Tiacoh
  • Malariology Department, Institut Pasteur, Côte d’Ivoire.
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N’tayé Lucien Aka
  • N’tayé Lucien Aka
  • Malariology Department, Institut Pasteur, Côte d’Ivoire.
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Ako Aristide bérenger Ako
  • Ako Aristide bérenger Ako
  • Malariology Department, Institut Pasteur, Côte d’Ivoire.
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Thierry-Borel Kouadio N’dri
  • Thierry-Borel Kouadio N’dri
  • Malariology Department, Institut Pasteur, Côte d’Ivoire.
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Stéphane Tosséa Koui
  • Stéphane Tosséa Koui
  • Malariology Department, Institut Pasteur, Côte d’Ivoire.
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André Offianan Toure
  • André Offianan Toure
  • Malariology Department, Institut Pasteur, Côte d’Ivoire.
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  •  Received: 01 June 2021
  •  Accepted: 10 August 2021
  •  Published: 13 August 2021

Abstract

Malaria is the world's leading parasitic endemic and the major cause of morbidity and mortality in Côte d'Ivoire. The aim of this study was to analyse the clinical aspects and evaluate a kit’s performance (NovaLisa® Malaria) against a panel of antigens (AMA1, GLURP, CSP and Schizont Extract) to determine the antigen used in diagnosing malaria serology in Côte d’Ivoire. A retrospective study was carried out on patients requesting malaria serological test. The ELISA technique and an antigen panel was respectively used for the multi-antigen approach and to measure the proportion of responders from 28 samples. 345 samples were assayed, with a positive rate of 92.49% (319/345) revealed by the malaria serology test with a mean concentration of 50.1 NTU, 6.38% (22/345) of negativity with a mean concentration of 5.96 NTU and 1.16% (4/345) in the doubtful zone (16.26 NTU). Mean concentration of prescriptions for cervical adenopathy was 73.12 NTU. The antigen panel seroprevalence was 35.72; 50; 64.28 and 78.5% respectively for AMA1, CSP, GLURP and schizont extract for negative samples and the proportion of responders was significant (p = 0.003) for schizont extract. The seroprevalence for the 28 samples was 60.7% for AMA1 and 89.29% for schizont extract. The proportions of responders to CSP (p = 0.008), GLURP (p < 0.001) and schizont extract (p < 0.001) antigens were significantly higher than those of non-responders. GLURP antigen and schizont extract could be used for diagnosing malaria serology in Côte d'Ivoire.

Key words: Malaria, Plasmodium falciparum, antigen, serodiagnosis.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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