Out of 156 samples collected from non-patients, nose and ear, 32% were found to harbor Staphylococcus aureus. Also 26 hospitals strains of S. aureus were isolated from clinical specimens. 62% of the total isolates including the clinical isolates were found to be multiple resistant, being resistant to 4 or more types of antibiotics. Resistance to methicillin and co-trimoxazole were the highest (76%) while resistance to gentamycin and erythromycin were the lowest (32%). Of the 74 strains, 62% were found to exhibit multiple resistant to 4 or more antimicrobial agents tested. 47% of the antibiotic resistant strains harboured plasmids ranging in molecular sizes from 0.282 kb and grouped into 6 plasmid profiles. Transformation experiment revealed that 41.2% of the resistant strains carried resistant plasmids of sizes 1.26, 23.13 and 25.12 kb. Plasmid-mediated resistance to amoxycillin, tetracycline and chloramphenicol was found.
Key words: Plasmids, Staphylococcus aureus, antibiotics, resistance.
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