Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2767

Full Length Research Paper

Exploring the association between diabetes mellitus and hearing loss: Genetic mutation, neuropathy and microangiopathy

Muhammad Firman Akbar
  • Muhammad Firman Akbar
  • Department of General Health Service, Sahabat Sehat Clinic, Jl Pariwisata No.16 Batu Layar, 83551 Lombok Barat, Nusa Tenggara Barat, Indonesia.
  • Google Scholar


  •  Received: 16 May 2016
  •  Accepted: 14 July 2016
  •  Published: 30 July 2016

Abstract

Diabetes mellitus (DM) has progressively increased in global prevalence. Recent studies have found that patients with DM may suffer from hearing impairment as a chronic complication. The effect of hearing loss may impair the quality of life of patients which affects functional, social, as well as psychological aspects. Both DM and hearing loss are considered to be associated, although this correlation remains elusive. There are three theories proposed to establish the association, which are microangiopathy, neuropathy and genetic mutation in mitochondrial DNA (mtDNA). This essay will initially discuss the importance of mtDNA mutations and neuropathy, as well as microangiopathy, in developing the expression of deafness in diabetes mellitus. It will also consider the limitation of these respective theories to explain the mechanism of hearing loss in diabetes mellitus patients.

Key words: Diabetes mellitus, hearing loss, mtDNA mutation, microangiopathy, neuropathy.