Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2722

Review

Nanomedicines: Challenges and perspectives for future nanotechnology in the healthcare system

Ajazuddin
  • Ajazuddin
  • Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, India, 490 024.
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Sabahuddin Siddique
  • Sabahuddin Siddique
  • Patel College of Pharmacy, Madhyanchal Professional University, Bhopal, Madhya Pradesh, India.
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Amit Alexander
  • Amit Alexander
  • Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, India, 490 024.
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Pooja Yadav
  • Pooja Yadav
  • Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, India, 490 024.
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Mukta Agrawal
  • Mukta Agrawal
  • Rungta College of Pharmaceutical Sciences and Research, Kohka-Kurud Road, Bhilai, Chhattisgarh, India, 490 024.
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Ahmed M Shehata
  • Ahmed M Shehata
  • Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia.
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Mahmoud A Shaker
  • Mahmoud A Shaker
  • Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia
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Syed Ata Ur Rahman
  • Syed Ata Ur Rahman
  • Pharmaceutics and Pharmaceutical Technology Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia.
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Mohi Iqbal M Abdul
  • Mohi Iqbal M Abdul
  • Department of Pharmacology and Toxicology, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Kingdom of Saudi Arabia.
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Mohamed A. Shaker
  • Mohamed A. Shaker
  • Pharmaceutics Department, Faculty of Pharmacy, Helwan University, P. O. Box 11795, Cairo, Egypt.
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  •  Received: 01 February 2019
  •  Accepted: 29 March 2019
  •  Published: 15 April 2019

Abstract

A novel approach of combining nanotechnology to the pharmaceutical and biotechnological field resulted in the formation of nanomedicines. Nanomedicines have progressed to a more considerable extent for curing irremediable diseases such as neurological defects, cardiovascular defects, etc., because of its minute size which assists in increased surface area and hence a remarkable dissolution profile. In addition to the health care sector, modernization of nanotechnology has also been implemented in other industries like cosmetics, electronics, catalysis, and chemical industries. Nanoparticles can be made by using polymers, either lipids or inorganic compounds like metals. They can be prepared by using either top to bottom or bottom to top approach. Interestingly, polymeric nanoparticles have provided an enormous opportunity to alter the surface of the nanoparticles leading to better drug delivery and drug targeting. However, these have the potential to induce toxicity as well. Also, the toxicity profile still has to be investigated. Moreover, characterization of the nanomedicines is always trouble, which has created a gap between conventional drugs and nanomedicines.

Key words: Nanomedicines, polymeric nanoparticles, lipid nanoparticle, drug targeting, nanotoxicology.