Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2740

Full Length Research Paper

Preparation and identification of two new phthalocyanines and study of their anti-cancer activity and anti-bacterial properties

Shahriar Ghammamy1, Mina Azimi2 and Sajjad Sedaghat1*  
1Islamic Azad University, Malard Branch, Malard, Iran. 2Department of Chemistry, Faculty of Science, Islamic Azad University, Ardabil Branch, Ardabil, Iran.
Email: [email protected]

  •  Accepted: 24 September 2012
  •  Published: 05 November 2012

Abstract

Nickel phthalocyanines chloride and nickel phthalocyanines nitrate abbreviated as NiPcCl and NiPc (NO3) respectively were synthesized and characterized. These nickel phthalocyanines are prepared by reaction of phetalic anhydride with urea, ammonium chloride and ammonium heptamolybdate, nickel related salt. Characterization of them was made by microanalyses, Fourier transform infrared spectroscopy (FT-IR) and Ultra violet (UV) visible spectroscopies. The biological properties such as antitumor and antibacterial activities of these compounds were studied. These new compounds showed excellent anti-tumor activity against colon cancer. The anti-bacterial properties of these compounds were studied on Gram-negative and Gram-positive bacterizes, such as Escherichia coli, Pseudomonas aeruginosa, Salmonella, Staphylococcus aureus, Bacillus subtilis.

 

Key words: Nickel phthalocyanines, synthesis, characterization, biological properties, anticancer, anti-bacterial.