Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2754

Full Length Research Paper

Sex steroid induced changes on the morphology of prostate of sprague-dawley rats

Olamide A. Adesanya1*, Kayode A. Oluyemi1, Nervey W. Dare2, Lukeman A.J. Shittu3,  Olusoji A. Oyesola4 and Abayomi O. Okanlawon5
1Department of Anatomy, School of Basic Medical Sciences, Igbinedion University, Okada, Edo State, Nigeria. 2Department of Anatomy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria. 3Department of Anatomy, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria. 4Department of Physiology, School of Basic Medical Sciences, Igbinedion University, Okada, Edo State 5Department of Anatomy, Lagos University College of Medicine, Idi Araba, Lagos, Nigeria.
Email: [email protected]

  •  Accepted: 02 April 2007
  •  Published: 30 August 2007

Abstract

The effects of combined administration of ethinylestradiol (E) and testosterone (T) were studied in castrated Sprague-Dawley rats. The hormones E and T were administered three times weekly on alternate days, subcutaneously in the inguinal region for 4 weeks, 30 days after castration. E- treated animals received injections of 3 μg/kg body weight (B.W), T- treated animals received 30 mg/kg B.W., combined testosterone and ethinylestradiol (T & E) - treated animals received injections of 30 mg/kg B.W. of T and 2 μg/kg B.W. of E. Control animals - were in two groups, castrated and intact both received injections of 5 ml/kg B.W. of normal saline. i) The T-treated prostate weight was significantly higher than in castrated control (P<0.05). (ii) The E- alone treated prostate weight was not significantly different from castrated control (P b0.05). iii) The combined T and E-treated prostate weight was significantly higher than in castrated control (P<0.05). Morphological findings: in the combined T and E-treated, the amount of connective tissue was well marked, there was an increase in the thickness of the epithelium and the size of the oval acini, relative to T-alone treated or the intact control. E-alone did not elicit any appreciable effect on the prostate, different from the castrated control. This finding demonstrates a synergistic effect of E on the prostate when administered along with T and also suggests that E may be involved in the pathophysiology of the abnormal enlargement of prostate gland.tc \l4 " (i) The T-treated and combined T and E-treated prostate weight were significantly higher  (P<0.05) than in castrated control.  (ii) The E-treated prostate weight was not significantly different (P <0.05) from castrated control. (iii)  In the combined T and E-treated prostate, the amount of connective tissue was well marked. The size of the oval acini, and the epithelium were increased relative to T-alone treated or the intact control.  These findings demonstrate the morphological changes induced by E on the prostate when administered along with T and also suggest that E may be involved in the pathophysiology of the postate gland.

 

Key words:  Prostate, castration, testosterone, ethinylestradioltc \l3 "Key Words: Prostate, Castration, Testosterone, Ethinylestradiol, histology.