Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2748

Full Length Research Paper

Tracheal relaxant effect of aqueous-methanol leaf extract of Rumex vesicarius L. in rabbits

Imran Ahmad Khan
  • Imran Ahmad Khan
  • Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Google Scholar
Khalid Hussain Janbaz
  • Khalid Hussain Janbaz
  • Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Google Scholar
Abdul Aziz
  • Abdul Aziz
  • Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
  • Google Scholar
Muzammal Sattar
  • Muzammal Sattar
  • Departmnent of Physiology and Pharmacology, University of Agriculture, Faisal Abad, Pakistan.
  • Google Scholar
Shaukat Hussain Munawar
  • Shaukat Hussain Munawar
  • Faculty of Medicine and Allied Medical Sciences, Isra University, Islamabad, Pakistan.
  • Google Scholar
Zahid Manzoor
  • Zahid Manzoor
  • Faculty of Medicine and Allied Medical Sciences, Isra University, Islamabad, Pakistan.
  • Google Scholar
Muhammad Asif Raza
  • Muhammad Asif Raza
  • The Ghazi University, Dera Ghazi Khan, Pakistan.
  • Google Scholar
Ghayoor Fatima
  • Ghayoor Fatima
  • Organic Plant Production and Agroecosystems Research in the Tropics and Subtropics, University of Kassel, Germany.
  • Google Scholar
Abdul Hannan
  • Abdul Hannan
  • Departmnent of Plant Pathology, University of Agriculture, Faisal Abad, Pakistan.
  • Google Scholar


  •  Received: 13 May 2014
  •  Accepted: 01 July 2014
  •  Published: 28 February 2015

Abstract

Rumex vesicarius L. has traditionally been used in folkloric medicine to manage respiratory disorders. The present study was designed to evaluate the effect of aqueous-methanol extract of R. vesicarius on isolated rabbit tracheal preparations, an attempt to validate its folkloric use in traditional medicine for respiratory ailment. The application of the extract to isolated rabbit tracheal preparations relaxed completely the carbachol-(1 μM) induced contractions (0.01 to 3.0 mg/mL) as well as K+-(80 mM) induced contractions (0.01 to 5.0 mg/mL). These effects were found comparable to that of dicyclomine, as an antagonist of muscarinic receptors as well as a possible Ca++ channel blocker. The previously mentioned findings may partially justify the folkloric use of R. vesicarius in the management of conditions pertaining bronchitis, asthma, chronic obstructive pulmonary disease and airy way congestion.
 
Key words: Rumex vesicarius, asthma, trachea, congestion, dicyclomine.