Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2755

Full Length Research Paper

Post-market in vitro bioequivalence study of six brands of ciprofloxacin tablets/caplets in Jos, Nigeria

N. C. Ngwuluka1, K. Lawal1, P. O. Olorunfemi1 and N. A. Ochekpe2*
  1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Jos, P. M. B. 2084, Jos, Nigeria. 2Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, University of Jos, P. M. B. 2084, Jos, Nigeria.
Email: [email protected]

  •  Accepted: 18 February 2009
  •  Published: 30 April 2009

Abstract

 

Six brands of ciprofloxacin 500 mg tablets have been evaluated using some quality control tests of uniformity of weight, hardness, friability, assay, disintegration and dissolution with the aim to assess its bioequivalence. The results obtained have been discussed in some details using monographs in the two Pharmacopeia (United States Pharmacopeia, USP and British Pharmacopeia, BP). The results were also subjected to statistical analysis. In particular, the dissolution test results were subjected to further tests to determine significance of ANOVA, significance of Dunnett’s test, dissolution efficiency, difference factor (f1) and similarity factor (f2). Subsequently the results indicated that 3 of the 6 (50%) brands may not be used interchangeably with the chosen ‘innovator’ brand.

 

Key words: Quality control tests, bioequivalence, ciprofloxacin, dissolution, dissolution efficiency, weight variation, disintegration.