Abstract

Bone morphogenetic proteins (BMPs) induce bone formation and healing. Bone can form in extraskeletal tissue in response to trauma and elevating BMPs. Several BMPs stimulated to increase due to neuroprotective effect. To get the injured zone of fraction warm is one of the suggested methods to prevent heterotopic ossification (HO). But about half of patients get the worst clinical situation. Montecarlo simulation was done with Hyperchem 8 and Ramachandran plot were designed with VMD 1.8.2. pdb files of both 1 tfg and 2 tgi proteins were selected from Protein Data Bank. φ and ψ of all 110 amino acid were calculated in both proteins after Montecarlo simulation at 290, 310 and 315 K for 200 ps, surrounded by water. 1 tfg is affected by increasing the temperature. The favored and allowed regions were decreased in population of dihedral angles. Increasing the temperature more than room temperature can cause more allowed dihedrals for 2 tgi. It is suggested that utilization of thermogenerator lamp progress the HO in such patients.

Key words: Transforming growth factor, bone morphogenic proteins, post traumatic heterotopic ossification.

Abbreviation

BMPs, Bone morphogenetic proteins; HO, heterotopic ossification; TGF-β, transforming growth factor β; MC, monte carlo