Abstract

The antibacterial potential of the crude leaves extracts of Psidium guajava Linn. against some bacteria associated with surgical wound, burns, skin and soft tissue infections were investigated under different conditions. Phytochemical screening of the crude leaves extracts revealed the presence of some bioactive compounds that have been associated with antimicrobial activities. Aqueous extracts was more potent in inhibiting the growth of pathogenic Proteus mirabilis, Streptococcus pyogenes, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa than the organic extracts. The gram-negative bacteria were less susceptible to the effects of the crude drugs. The MIC and MBC values ranged between 6.25 - 50 mg/ml, depending on extracting solvent and the bacterium in question. Based on the diameters of zones of growth inhibitions, the crude extracts were more effective under acidic conditions and also at low temperatures. The plant can be used for the formulation of oral antibacterial drugs to manage surgical, skin and soft tissue infections.

Key words: Psidium guajava, antibacterial potential, bioactive compounds, surgical, soft tissue.