Scientific Research and Essays

  • Abbreviation: Sci. Res. Essays
  • Language: English
  • ISSN: 1992-2248
  • DOI: 10.5897/SRE
  • Start Year: 2006
  • Published Articles: 2716

Full Length Research Paper

Antimicrobial activity and phytochemical screening of crude water extract of the stem bark of Ficus glumosa.

H. A. Kwazo1, U. Z. Faruq2*, S. M. Dangoggo2, B. S. Malami3 and D. O. Moronkola
1Department of Chemistry Shehu Shagari College of Education Sokoto, Nigeria. 2Department of Pure and Applied Chemistry Usmanu Danfodiyo University Sokoto, Nigeria. 3Department of Animal Science, Usmanu Danfodiyo University Sokoto, Nigeria. 4Department of Chemical Sciences, Olabisi Onabanjo University, Nigeria.
Email: [email protected]

  •  Received: 03 December 2013
  •  Accepted: 03 July 2014
  •  Published: 15 March 2015

Abstract

Water and methanol extracts of the stem bark of Ficus glumosa were screened for their antimicrobial properties against Salmonella species. Preliminary results showed that the active compound was in the water extract. Therefore, the water extracts (hot and cold) were subjected to column chromatographic fractions and antibacterial screening. The most active fraction was subjected to phytochemical screening and finally Gas Chromatography Mass Spectrography (GC/MS) analysis. The result indicated that the most active fraction was the 3rd hot water extract and its GC/MS analysis was narrowed down to  3,3’-(4-methyl-1,3-phenylene)bis(1-heptylurea), isothujol and Terbuthyl azine. 
 
Key words: Phytochemical screening, Ficus glumosa, column chromatography and antimicrobial activity.