Artemisins remain the drug of choice in the treatment of uncomplicated malaria. Liposomes encapsulating artemether and lumefantrine were formulated through the thin-layer evaporation method. The liposomes were evaluated for particle size, polydispersity index, encapsulation efficiency, stability studies using Triton-X. Results show mean particle sizes for the empty liposomes at 120.7 nm +4.52 with polydispersity index (PI) of 0.142 nm +0.007 while the drug-loaded liposomes had a mean particle size of 108.7+8.36 and PI of 0.197+0.01. The encapsulation efficiency (EE) for artemether was 79.4 % while the EE for lumefantrine was 36.1 %. The molarity of the S75 in the liposome was 24 mM. The 3 mM of liposomes was disrupted with 15 µL of 10 mM Triton-X.
Keywords: Liposomes, conventional, artemether, lumefantrine, parenteral