WANNPRES Conference 2018

30th May – 2nd June, 2018

Western Africa Network of Natural Products Research Scientists

Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences University of Nigeria, Nsukka, Nigeria.


Effects of aqueous extract of kuding leaves on cyanide-induced toxicity and packed cell volume (PCV)

Cyanide poisoning occurs when a living organism is exposed to a compound that produces cyanide ions (CN−) when dissolved in water. Kuding leaves are Chinese leaves used for weight control. Aqueous extract of kuding leaves was assessed for its effect on cyanide-induced toxicity and packed cell volume (PCV) in Wistar rats. Group A was administered 1% Tween-80 at 5 ml/kg. Group B was not induced but received 400...

Author(s): Obiajulu Christian Ezeigwe, Christopher Onyemeziri Alisa and Josephine Ezekwesili-Ofili

  • Article Number: 3518D12

Promotion of wound healing in mice using a formulation of Ficus sur Forssk aqueous leaf extract

Injuries from accidents are frequent occurrences. In most developing countries, patronage of alternative medicines to treat such injuries is common. Ficus sur Forssk (Moraceae) leaves are used for wound management in alternative medicine in Northern Nigeria. This study aimed at determining the effect of a formulation of the aqueous extract of F. sur on wound healing. A decoction of powdered leaves of F. sur was prepared...

Author(s): Lucy B. John-Africa, Christianah YIsimi, Medina Abbas and Aisha Daburi  

  • Article Number: B60E616

Effects of n-Hexane fraction of Gongronema latifolium on some biochemical parameters in alloxan-induced diabetic albino Wistar rats

Diabetes mellitus is a burden affecting both developed and developing countries of the world and it has been known to be associated with hyperglycaemia, lipid disorders and cardiovascular complications. This work was undertaken to ascertain the effects of the n-Hexane leaf fraction of Gongronema latifolium as an anti-diabetic agent using standard methods. The results indicated a significant percentage increase...

Author(s): Grace Sylvester Effiong, Grace Emmanuel Essien, Adedayo Adedoyin Tologbonse and Danladi Ngyan Bala

  • Article Number: D259622

Effect of methanol extract of Synsepalum dulcificum pulp on some biochemical parameters in albino rats

Synsepalum dulcificum is believed to have medicinal and nutritional potentials. The objective of this study was to determine the beneficial effects of the methanol extract of the plant on some biochemical parameters such as liver function tests (alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate transaminase (AST), total bilirubin, total protein, albumin and globulin), blood glucose levels and...

Author(s): Nkwocha, Chinelo Chinelo, Nworah, Florence Nkechi, Nwagwe, Ruth Onyinyechi and Njoku, Obioma Uzoma  

  • Article Number: E78B526

Effect of Senna mimosoides leaf aqueous extract on the lactase activity, total protein and the electrolyte-inducing potentials of carbon tetrachloride induced hepatoxicity in Wistar albino rats

Aqueous extract of Senna mimosoides leaves (ASML) (a common weed in Savannah region of the African Continent) has been used in management of lactose intolerance and breast toxicity by locals. This study evaluated phytoconstituent of the aqueous extract of S. mimosoides leaves and the effect on lactase activity and subsequent electrolyte-inducing potentials. Thirty female albino rats were used for this study and were...

Author(s): NWORAH Florence Nkechi, NKWOCHA Chinelo Chinenye and NWACHUKWU Justus Nmaduka

  • Article Number: EBB6428

Evaluation of the anti-inflammatory activity of the Commelina ascendens J.K Morton (Commelinaceae) aerial part extract

This study evaluated the anti-inflammatory effect of Commelina ascendens using experimentally induced inflammatory models in rats. Oedema was induced on the rat hind paw by the injection of 0.1 mL of undiluted fresh egg albumin (phlogistic agent) into the subplantar surface of the right rat paw. Oedema was assessed in terms of volume of distilled water displaced by the paw. Tissue granuloma was induced in the rats by...

Author(s): Akachukwu Marytheresa Onwuka, Chukwuemeka Sylvester Nworu, Ikechukwu Emmanuel Peter, Florence Nwakaego Mbaoji, Bonaventure Chukwunonso Obi, Azubuike Collins Onyeto, Ifeoma Amarachukwu Nwabunike, Ogechukwu Nnanyelugo Isiogugu, Nneoma Martha Ofokansi, Ogbonnaya Charles and Peter Achunike Akah

  • Article Number: 86EA232

Effects of Monodora myristica (Gaertn, Dunal.) (Annonaceae) root bark on acute and chronic inflammation

Several researches have established the antioxidant, antibacterial and anti-inflammatory activities of the seeds and stem bark of Monodora myristica while scientific data on the pharmacological activities of the roots is sparse. Hence, this work evaluated the effects of methanol extract of the root bark of M. myristica on acute and chronic inflammation. The root bark was extracted by cold maceration in methanol to yield...

Author(s): Ogechukwu Nnanyelugo Isiogugu,  Adaobi Chioma Ezike,  Ikechukwu Emmanuel Peter,  Akachukwu Mary Onwuka,  Bonaventure Chinonso Obi,  Uche Collins Abonyi  

  • Article Number: 7724C36

Preliminary investigation of the anti-inflammatory activity of Harungana madagascariensis leaf extract Lam.Expoir (Hypericaceae)

The anti-inflammatory activity of Harungana madagascariensis (Hypericaceae) leaf was evaluated using formaldehyde-induced acute edema and arthritis respectively, and cotton pellet granuloma in rats. The leaf extract was obtained by cold maceration in methanol:dichloromethane (1:1) for 72 h. The extract was also subjected to acute toxicity test and phytochemical analysis. Acute toxicity test revealed that the extract had...

Author(s): Medewase, J. O and Ezike, A. C.    

  • Article Number: 0D49695