Abstract

As an important inflammatory marker, plasma interleukin-6(IL-6) is associated with type 2 diabetes. However, the distribution of C-572G polymorphism of the IL-6 and its association with type 2 diabetes in Han population are still unclear. The objective of this study was to explore the distribution of C-572G polymorphism in healthy Han subjects and to evaluate the association between the human interleukin-6 C-572G polymorphism and type 2 diabetes in Han population. In cohort one, 326 nondiabetic subjects were analyzed and found there were no differences about clinical and chemistry characteristics including SBP, DBP, BMI, FBG, Fins, TC, LDL, TG, HDL, WHR, even in age and gender in the -572G/G, -572C/G and -572C/C genotype. In cohort two, 358 Han subjects with type 2 diabetes mellitus, significant difference were observed among the -572G/G, -572C/G and -572C/C genotype especially in TG, FBS, FINS and HOMA-IR. The concentration of plasma IL-6 in cohort two was measured and found that there was a significant association between genotypes and plasma IL-6 concentration (G/G vs G/C vs C/C: 8.29±2.77pg/ml vs 6.08±1.62 pg/ml vs 6.46±1.48 pg/ml; P=0.013, for C/C vs G/G; P=0.040, for C/G vs G/G). It may be concluded that there is a significant association between C-572G and T2DM in Liaoning Han population.

Key words: Interleukin 6, C-572G polymorphism, type 2 diabetes, Liaoning Han population.