International Journal of
Physical Sciences

  • Abbreviation: Int. J. Phys. Sci.
  • Language: English
  • ISSN: 1992-1950
  • DOI: 10.5897/IJPS
  • Start Year: 2006
  • Published Articles: 2569

Full Length Research Paper

Protective effect of Morinda officinalis polysaccharides on bone degeneration in the aged rats

Zong-Bao Wang1，Qing-You Lu2*，Hai-Yan Lu1，Wei-Ming Liao3, Zhuo-Peng Wu1，Guang-Zhi Kuang1，Hua-Jie Feng1
1Science Research Base of Kaiping Central Hospital, Postdoctoral Mobile Station of Sun Yat-sen University, Kaiping 529300, China. 2Department of Traumatic Surgery, Dongfang Hospital Affiliated to Tongji University, Shanghai 200120, China. 3Department of Orthopedic, First Hospital Affiliated to Tongji University，Guangzhou 510700，China.
Email: [email protected]

  •  Accepted: 22 December 2010
  •  Published: 04 January 2011

Abstract

In the current study, we examined the effect of Morinda officinalis polysaccharides (MOP) on bone quality in aged rats. Rats were given orally by daily gavage at 200 and 400 mg/kg/day for 3 months, respectively. The results showed that there was a significant decrease in serum alkaline phosphatase (ALP), Interleukin 6 (IL-6) content and a significant increase in density and strength of femur and lumbar vertebrae in aged rats 3 months afterMorinda officinalis polysaccharides treatment. In conclusion, these data suggest thatMorinda officinalis polysaccharides can protect the age-induced bone degeneration.

 

Key words: Morinda officinalis polysaccharides, bone, osteoporosis, ALP.

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