Abstract

The brain slice can be placed on the perforated substrate of the chip that it is supplied with nutrients, drugs and gas from both above and below. The nano – electrode (chip) can be used as a shape for larger contact area and stronger interaction with brain tissue. These electrodes should be penetrated the brain slice without damaging the tissue too much. There are two significant issues in nano-chip, such as oxide and silicon can threaten the tissue system, because they can make unwanted bonds and affect brain tissue. We thus heated nano-chip in the ultra high vacuum (UHV) by passing current through the sample and we could get a clean nano-chip without silicon and oxygen. The obtained results show that the tilted electrode may damage brain tissue more than that untitled electrode and so the tilted electrode should not be used in brain treatment, because the porous of the electrode may be filled with undesirable materials.

Key words: Nano–chip, brain tissue, backscattered electrons yield.