African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

In vitro study of the interaction between some fluoroquinolones and extracts of kola nitida seed

IBEZIM, E. C.1, ESIMONE, C. O.1, NNAMANI, P. O.1, ONYISHI, I. V.2, BROWN, S. A.3 and OBODO, C. E.4
1Department of Pharmaceutics, University of Nigeria, Nsukka. 2Department of Pharmaceutical Technology and Industrial Pharmacy, University ofNigeria, Nsukka. 3Department of Pharmaceutics and Pharmaceutical Technology, University of Uyo. 4Department of Clinical Pharmacy and Pharmacy Management, University of Nigeria, Nsukka.
Email: [email protected]

  •  Accepted: 15 May 2006
  •  Published: 02 October 2006

Abstract

The cup diffusion method (CD) was used to evaluate the in vitro interaction of some fluoroquinolones (ciprofloxacin, pefloxacin and levofloxacin) with extracts ofKola nitida seed (KNS) against a clinical isolate of Escherichia coli. Minimum inhibitory concentration (MIC) of the drugs was determined separately and in combination with KNS extract in ratios of 0:5, 1:4, 2:3, 3:2, 4:1 and 5:0 against E. coli. The result of the study revealed that the MIC of the drugs decreased when combined with KNS extract. In other words, KNS extract potentiated the effects of the fluoroquinolones against E. coli.

 

Key words: Interaction study, ciprofloxacin, pefloxacin, levofloxacin, Kola nitida seed

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This article is published under the terms of the Creative Commons Attribution License 4.0

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