African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12296

Full Length Research Paper

Pharmacokinetics of mequindox after intravenous and intramuscular administration to goat

  Yinqian Li, Wenyan Xie, Xiaoying Zhang*, Zehua Tian and Caiju Hao  
College of Veterinary Medicine, Northwest A & F University, Yangling, China, 712100.
Email: [email protected]

  •  Accepted: 15 November 2010
  •  Published: 06 December 2010

Abstract

 

Pharmacokinetics and bioavailability of mequindox were determined after single intravenous (i.v.) or intramuscular (i.m.) administrations of 7 mg/kg body weight (b.w.) to 10 healthy adult goats. Plasma mequindox concentrations were measured by high performance liquid chromatography. Pharmacokinetics were best described by a two-compartment open model and an one-compartment open model for i.v. and i.m. groups, respectively. The elimination half-life and volume of distribution after i.v. and i.m. administrations were statistically different (t1/2β, 1.8 to 1.5 h, P < 0.05 and Vd, 0.35 to 0.45 L·kg-1, P < 0.05, respectively). Mequindox was rapidly (t1/2a, 0.28 h) and almost completely absorbed (F, 99.8%) after i.m. administration. In conclusion, 2~3 times daily i.v. and i.m. administration of mequindox (7 mg/kg b.w.) in goats may be useful in treatment of infectious diseases caused by sensitive pathogens. The plasma disposition kinetics of mequindox in goats is reported for the first time.

 

Key words: Mequindox, pharmacokinetics, high performance liquid chromatography (HPLC), goats.

Abbreviation

 

Abbreviations: i.v., Intravenous; i.m., intramuscular; HPLC, high performance liquid chromatography; AIC, Akaike’s Information Criterion.