African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Short Communication

In vivo activities of Baicalin against Chlamydia trachomatis

Qi Xiaojuan1,2, Fu lei1, Su Wen1,Yi Yandong1 and Huang Hao1*
1Center of Experimental Medicine, Wuhan First Hospital, Wuhan City 430022, P.R. China. 2Maternal and Child Care Service Centre in Wuhan's Qingshan District, Wuhan City 430022, P.R. China.
Email: [email protected]

  •  Accepted: 19 January 2010
  •  Published: 15 March 2010

Abstract

Our previous studies have shown that Baicalin could effectively inhibit Chlamydia trachomatis in vitro. In this study, Baicalin was tested for potential antichlamydial activity using a murine genital Chlamydia trachomatis infection model. It was demonstrated that Baicalin significantly reduced C. trachomatis loading in BALB/c mice that were vaginally infected with the pathogen. On the basis of these data and our previous observations, we concluded that further evaluation of Baicalin for prevention and treatment of sexually transmitted chlamydial infection is warranted.

 

Key words: Chlamydia trachomatis, Baicalin, vaginally infected.

Abbreviation

HIV, Human immunodeficiency virus; HPLC, high performance liquid chromatography.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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