The effect of Trypanosoma congolense infection on plasma kinetics of intravenously administered lactose was investigated in apparently healthy and T. congolense infected rams. Four rams infected with T. congolense and 4 uninfected rams were each infused intravenously with repeated doses of 0.5 g/kg body weight lactose in saline, thrice daily at 4 h interval. Blood was collected at specified intervals and analyzed for residual lactose. Plasma kinetic parameters such as biologic half-life (t1/2), elimination rate constant (Ke), total clearance (CT) and volume of distribution (Vd) were calculated from the data obtained. The mean values for the t1/2, Ke, Vd and CT for the infected group were 5.328 ± 1.045, 1.682 ± 0.289 h-1, 508.75 ± 41.987 ml/kg and 68.378 ± 1 7.571 ml/kg/h, respectively. The mean values for the uninfected group were 5.336 ± 0.753, 2.408 ± 0.817 h-1, 517.00 ± 196.592 ml/kg and 53.223 ± 14.888 ml/kg/h respectively. Infection with T. congolense significantly affected only the elimination rate constant Ke.
Key words: Trypanosoma congolense, trypanosomosis, lactose.
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