African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12191

Short Communication

Anti-diabetic properties of Securinega virosa (Euphorbiaceae) leaf extract

Y. Tanko1*, M. A. Okasha1, G. M. Magaji2    M. Yerima2, A. H. Yaro3, M. I. A.Saleh1 and A. Mohammed1
1Department of Human Physiology, Ahmadu Bello University, Zaria, Nigeria. 2Department of Pharmacology and Clinical Pharmacy Ahmadu Bello University, Zaria, Nigeria. 3Department of Pharmacology, Bayero University, Kano, Nigeria.
Email: [email protected]

  •  Accepted: 05 December 2007
  •  Published: 04 January 2008

Abstract

This study was undertaken to evaluate the hypoglycemic effect of methanol extract ofsecurinega virosa leaves on blood levels of streptozocin-induced diabetes rats. Three doses of the extract (100, 300 and 600 mg/kg) were administered intraperitoneally. After 2 h of extract administration there was no significant change in the blood glucose levels in all the three doses of the extract. Also after 4, 8 and 24 h of extract administration there was a significant (p < 0.05 - 0.001) decrease in the blood glucose levels in all the three doses of the extract. The preliminary phytochemical screening revealed the presence of reducing sugars, cardiac glycosides, resin, tannins, saponins, glycosides, flavonoids, glycerin carbohydrate, anthraquine and steroids. The median lethal dose (LD50) in rats was calculated to be 1264.9 mg/kg body weight.

 

Key words: Securinega virosa, hypoglycemic activity, streptozocin, diabetes mellitus.