African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Primary drug resistance patterns in newly diagnosed tuberculosis patients in Yazd, Southern Province of Iran

  Sharifi Yazdi M. K.1, 2*, Jabbari H.3, Soltan Dallal  M. M,4 and Bahrmand A.5  
  1Department of Medical Laboratory Sciences, School of Paramedicine, Tehran University of Medical Sciences. Tehran, Iran. 2Zoonosis Research Center, Tehran University of Medical Sciences, Tehran, Iran. 3Infectious Diseases Department, Digestive Diseases Research Center, Tehran University of Medical Sciences, Tehran Iran. 4Division of Microbiology,  Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. 5Pasteur Institute of Iran, Department of Mycobacteriology, and pulmonary Research, Tehran,Iran.
Email: [email protected]

  •  Accepted: 28 December 2011
  •  Published: 10 January 2012

Abstract

 

Prevalence of multidrug resistant (MDR) and extensively drug-resistant tuberculosis (XDR) has been a cause of concern for tuberculosis (TB) control in both developed and developing countries. The objective of this study was to investigate the prevalence of drug resistance patterns among newly diagnosed tuberculosis cases, in Yazd, the southern province of Iran, during 2009 to 2010. The drug susceptibility testing (DST) was performed for 31 culture-positive individuals. The strains that were identified as MDR were subjected to susceptibility testing for second line drugs. The highest rate of resistance was to ethinoamide (51.61%), followed by kanamycin (29.03%), streptomycin (25.8%), rifampine (22.58%), isoniazid (6.45%), and ethambutol (3.2%). Drug resistance to both isoniazid and rifampin was identified in 2 cases.

 

Key words: Tuberculosis, drug resistance, multidrug-resistant tuberculosis, extensively drug-resistant tuberculosis.

Abbreviation

MDR, Multidrug resistant; TB, tuberculosis; XDR, extensively drug-resistant tuberculosis; DST, drug susceptibility testing.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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