African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12479

Full Length Research Paper

Studies on cytotoxicity and antitumor screening of red and white forms of Abrus precatorius L.

R. Sivakumar1 and C. Alagesaboopathi2*
  1Department of Biotechnology, S.N.R. Sons College, (Autonomous), Coimbatore – 641 006, Tamilnadu, India. 2Department of Botany, Government Arts College (Autonomous), Salem – 636 007, Tamilnadu, India.
Email: [email protected]

  •  Accepted: 29 May 2008
  •  Published: 19 November 2008

Abstract

 

The cytotoxicity study with cancer cell line A-549 indicated that the methanol insoluble fraction of crude red forms of Abrus precatorius is toxic (CTC50 175,100mg/ml) in microculture tetrazolium assay and sulphorhodamine B assays, whereas crude and fractions of the red and white forms exhibited toxicity at still higher concentrations. However, an antitumor screening by the short-term toxicity study with DLA cells showed the extracts to be comparatively less toxic.

 

Key words: Abrus precatorius, cytotoxicity, antitumor, medicinal plants.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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