African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Anti-HIV-1 protease activities of crude extracts of some Garcinia species growing in Tanzania

Joseph J. Magadula1* and Supinya Tewtrakul2
1Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, Box 65001, Dar Es Salaam, Tanzania. 2Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat-Yai, Songkhla, 90112, Thailand.
Email: [email protected]

  •  Accepted: 11 June 2009
  •  Published: 22 March 2010

Abstract

Eighteenth ethanol extracts from some Garcinia species in the Guttiferae (Clusiaceae) family collected in Tanzania were investigated for their HIV-1 protease (HIV-1 PR) inhibitory activities using high performance liquid chromatography (HPLC). Among the tested extracts, the fruit hulls of Garcinia semseii showed the most potent inhibitory activity against HIV-1 PR with an IC50 value of 5.7 µg/ml followed by the stem bark extracts of Garcinia edulis and Garcinia kingaensis with IC50 values of 9.2 and 15.2 µg/ml, respectively. Phytochemical screening of extracts indicated mostly the presence of phenolic and steroidal compounds.

 

Key words: Garcinia species, clusiaceae, crude extracts, HIV-1 protease, inhibitory effect.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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