African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12392

Full Length Research Paper

Anti-inflammatory and antioxidant potentiality of Solanum xanthocarpum

Rohini Pungle
  • Rohini Pungle
  • Department of Biotechnology, Shivchhatrapati College, Aurangabad, India.
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Aditya Tambe
  • Aditya Tambe
  • Department of Biotechnology, Shivchhatrapati College, Aurangabad, India.
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Anil More
  • Anil More
  • Department of Biotechnology, Shivchhatrapati College, Aurangabad, India.
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Arun Kharat
  • Arun Kharat
  • Department of Biotechnology, Dr. Babasaheb Ambedkar Marathwada University, Subcampus Osmanabad, MS, India.
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  •  Received: 18 June 2018
  •  Accepted: 03 September 2018
  •  Published: 12 September 2018

Abstract

Inflammation is the body’s immune response to combat suspected harmful effect by a stimulus. Antioxidants prevent chain of reaction that would result in the production of free radicals. Prolonged usage of steroids as anti-inflammatory agents is unsafe, demanding search for anti-inflammatory compounds with sustainable future. In this study, seeds and leaves of Solanum xanthocarpum were explored in vitro for their anti-inflammatory and antioxidant activity. The ethanolic extract of seeds and leaves of S. xanthocarpum was prepared by maceration. Anti-inflammatory activity of ethanolic extract of seeds (SE) and leaves (LE) was evaluated in terms of percent inhibition of albumin denaturation, membrane stabilization and protease inhibition. The antioxidant activity was estimated by 2,2-diphenyl-1-picrylhydrantiiazyl (DPPH) free radical scavenging assay by exploiting 1,1-diphenyl-2-picrylhydrazine. Successive solvent extraction with maceration of seeds was carried out by using solvents ethanol, ethyl acetate, acetone and water. The ethanolic extracts of seeds and leaves of S. xanthocarpum demonstrates anti-inflammatory and antioxidant activity. The acetones extract exhibited potent anti-inflammatory activity than ethyl acetate and aqueous extract. Results presented here suggest that the S. xanthocarpum exhibits anti-inflammatory and antioxidant potentiality.

 

Key words: Solanum xanthocarpum, anti-inflammatory, phytochemical and antioxidant activity.