African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Antimicrobial susceptibility assessment of compound from Aspergillus fumigatus

Zakia Sultana Sathi*
  • Zakia Sultana Sathi*
  • Department of Pharmacy, Daffodil International University, Dhaka-1207, Bangladesh.
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Md. Mustafezur Rahman
  • Md. Mustafezur Rahman
  • Department of Pharmacy, Daffodil International University, Dhaka-1207, Bangladesh.
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Muhammad Arifur Rahman
  • Muhammad Arifur Rahman
  • Department of Pharmacy, Daffodil International University, Dhaka-1207, Bangladesh.
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Md. AL- Faruk
  • Md. AL- Faruk
  • Department of Pharmacy, Daffodil International University, Dhaka-1207, Bangladesh.
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Mohammad Abdur Rashid
  • Mohammad Abdur Rashid
  • Department of Pharmacy, Daffodil International University, Dhaka-1207, Bangladesh; Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh.
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  •  Received: 01 April 2014
  •  Accepted: 02 January 2015
  •  Published: 21 January 2015

Abstract

Ethyl acetate extract of the culture filtrate of Aspergillus fumigatus on chromatographic analysis has led to the isolation of the compound, AF-1 which exhibited a significant in vitro antimicrobial activity against the tested pathogenic microorganism. The structure of the isolated compound, AF-1 was identified as 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one from its IR, UV, EI-MS, 13C-NMR, 1H-NMR, HMBC and HMQC data. This is the first report of the compound, AF-1 from the A. fumigatus.

 

Key words: Aspergillus, 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one, antimicrobial screening, bioactive compound.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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