African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Antinociceptive and anti-inflammatory activities of the aqueous extract of the root bark of Combretum sericeum in rodents

  Sini, J. M.1*, Yaro, A. H.2, Ayanwuyi, L. O.3, Aiyelero, O. M.3, Mallum, S. M.4 and Gamaniel, K. S.5  
  1Department of Biochemistry, Faculty of Science, Ahmadu Bello University, Zaria, Kaduna State, Nigeria. 2Department of Pharmacology, Faculty of Medicine, Bayero University, Kano, Kano State, Nigeria. 3Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Kaduna State, Nigeria. 4Department of Biological Sciences, Faculty of Science, Ahmadu Bello University, Zaria, Kaduna State, Nigeria. 5Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development (NIPRD), Abuja F.C.T, Nigeria.  
Email: [email protected]

  •  Accepted: 05 November 2010
  •  Published: 20 December 2010

Abstract

 

Combretum sericeum (Combretacae) is used traditionally in Northern Nigeria for the treatment of fever. In this study, the activities of the aqueous extract of the root bark of this plant against nociception and inflammation were investigated in mice and rats. The studies were carried out using acetic acid writhing, hot plate algesia and carrageenan induced inflammation in rats. The results showed that the extract exhibited significant (P < 0.001) anti-nociceptive and anti-inflammatory activities in all the models used. Phytochemical screening of the extract revealed the presence of tannins, flavonoids, glycosides alkaloids and anthraquinones. The intraperitoneal median lethal dose (LD50) of the extract was found to be 177.48 mg/kg in mice. The observed activities might be the scientific basis for the traditional use of the plant in the treatment of fever. This study also paves way for the possible development of the plant extract as a phytodrug against pain and inflammatory conditions.

 

Key words: Combretum sericeum, anti-nociceptive, anti-inflammatory, hot plate algesia.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

Back to Vol. 9 No. 51
Back to articles
  • Articles on Google by:
SUBSCRIBE TO RSS
SUBMIT MANUSCRIPT
CONFERENCES