Abstract

Methanolic extract of Bombax buonopozense was evaluated for possible anti-nociceptive, anti-inflammatory and anti-pyretic activities in mice and rats. Acetic acid-induced abdominal constriction test in mice and formalin test in rats were used to investigate the antinociceptive effect of the extract. Studies were carried out on yeast-induced pyrexia and egg albumin-induced anti-inflammatory activity in rats. The extract produced a significant decrease in acetic acid-induced writhing in mice and inhibition of late phase of the formalin pain test in rats. The methanolic extract of B. buonopozense leaf also produced a potent antipyretic effect and significant inhibition of egg albumin-induced anti-inflammatory activity in rats. The result suggests that B. buonopozense contains biologically active substances with potential values for the treatment of fever, painful and inflammatory conditions.

Keywords: Bombax buonopozense; analgesic, inflammation, pyrexia.

Abbreviation

NSAID, Non-steriodal anti-inflammatory drug; i.p, intraperitoneally; ASA, acetylsalicylic acid; s.c, subcutaneously; PG, prostaglandin; TNF, tumor necrosis factor.