African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Antioxidant, antibacterial and α-glucosidase inhibitory activities of different extracts of Cortex Moutan

Jinfeng Yang1#, Ju-Sung Kim2#, Yeo Jin Sa1, Myeong Ok Kim1, Hyun Ju Jeong1, Chang Yeon Yu1 and Myong Jo Kim1*   #These authors contributed equally to this work.
1Department of Applied Plant Sciences, Kangwon National University, Chuncheon 200-701, Korea. 2Majors in Plant Resource Sciences and Environment, College of Applied Life Sciences, Jeju National University, Jeju 690-756, Korea.
Email: [email protected]

  •  Accepted: 27 June 2011
  •  Published: 22 August 2011

Abstract

Different extracts of Cortex Moutan (CM) were investigated for their antioxidant, antibacterial and α-glucosidase inhibitory activities. The content of paeonol was quantified by high performance liquid chromatography (HPLC). The results show that the yield of acetone extract (57.14%) was significantly higher than those of other solvents. The ethyl-acetate extract exhibited maximum paeonol concentration(60.69 μg/ml), good antibacterial activities (MIC = 100 μg/ml) against Escherichiacoli and possessed significant α-glucosidase inhibitory activity. In addition, among all of the extracts, ethyl-acetate extract demonstrated a high total phenolic value of127.12 ± 1.42 mg GAE/g, high DPPH radical scavenging activity with an IC50 of19.88 ± 0.26 μg/ml, and significant reducing power, suggesting that CM is a potential source of natural antioxidants.

 

Key words: Cortex Moutan, antioxidant, 11-diphenyl-2-picrylhydrazyl hydrate (DPPH), reducing power, antibacterial, α-glucosidase.

Abbreviation

CM, Cortex Moutan; DPPH, 1,1-diphenyl-2-picrylhydrazyl hydrate;TCM, traditional Chinese medicine; T2DM, type-2 diabetes

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This article is published under the terms of the Creative Commons Attribution License 4.0

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