Abstract

Helicobacter pylori, a gram negative bacterium is capable of being resistant to a wide spectrum of antimicrobial drugs. The prevalence of antibiotic resistance in H. pylori strains differs amongst distinct geographical areas and has increased worldwide. Therefore, information concerning the prevalence of antimicrobial-resistant H. pylori strains is important in predicting therapeutic response. In this study, drug susceptibility of H. pylori in patients was investigated in Laleh hospital, Tehran, Iran from 2007 - 2008. 104 antral biopsies of patients with non ulcer dyspepsia and peptic ulcer were cultured. Susceptibility patterns were determined by disk diffusion method. Minimum inhibitory concentration (MIC) was performed for resistant isolates of H. pylori. In our study, 51.5% of clinical isolates showed resistance to metronidazole. All of the isolates were sensitive to other antibiotic disks including clarithromycin, amoxicillin, tetracycline and furazolidone. MIC was determined as 16 µg/ml in 5.8% and 32 µg/ml in 94.1% of isolates for metronidazole resistance isolates. The results indicated that the major drug resisted by H. pylori is metronidazole and it should be considered when recommending drugs to patients in this region.

Key words: Helicobacter pylori, antimicrobial resistance, MIC.