African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12496

Full Length Research Paper

In-silico smart library design to engineer a xylose-tolerant hexokinase variant

Yasser Gaber
  • Yasser Gaber
  • Microbiology Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, 62511, Egypt.
  • Google Scholar


  •  Received: 02 November 2015
  •  Accepted: 19 April 2016
  •  Published: 25 May 2016

References

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Joosten HJ (2007). 3DM: from data to medicine. PhD Thesis, University of Wageningen, Wageningen, The Netherlands.

 
 

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Kuipers RK, Joosten HÄ, van Berkel WJ, Leferink NG, Rooijen E, Ittmann E, van Zimmeren F, Jochens H, Bornscheuer U, Vriend G (2010b). 3DM: systematic analysis of heterogeneous superfamily data to discover protein functionalities. Proteins: Structure, Function, and Bioinformatics 78(9):2101-2113.
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Kuser PR, Krauchenco S, Antunes OAC, Polikarpov I (2000). The High Resolution Crystal Structure of Yeast Hexokinase PII with the Correct Primary Sequence Provides New Insights into Its Mechanism of Action. J. Biol. Chem. 275(27):20814-20821.
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Moreno F, Herrero P (2002). The hexokinase 2-dependent glucose signal transduction pathway of Saccharomyces cerevisiae. FEMS Microbiol. Rev. 26(1):83-90
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Nishimasu H, Fushinobu S, Shoun H, Wakagi T (2007). Crystal Structures of an ATP-dependent Hexokinase with Broad Substrate Specificity from the Hyperthermophilic Archaeon Sulfolobus tokodaii. J. Biol. Chem. 282(13):9923-9931.
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Nobili A, Gall MG, Pavlidis IV, Thompson ML, Schmidt M, Bornscheuer UT (2013). Use of 'a small but smart' libraries to enhance the enantioselectivity of an esterase from Bacillus stearothermophilus towards tetrahydrofuran-3-yl acetate. FEBS J. 280(13):3084-3093.
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Trott O, Olson AJ (2010). Auto Dock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput. Chem. 31(2):455-461.

 
 

Wang M, Si T, Zhao H (2012). Biocatalyst development by directed evolution. Bioresour. Technol. 115:117-125.
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Wijma HJ, Janssen DB (2013). Computational design gains momentum in enzyme catalysis engineering. FEBS J. 280(13):2948-2960.
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