African Journal of
Biotechnology

  • Abbreviation: Afr. J. Biotechnol.
  • Language: English
  • ISSN: 1684-5315
  • DOI: 10.5897/AJB
  • Start Year: 2002
  • Published Articles: 12487

Full Length Research Paper

Biogenic synthesis of silver nanoparticles using Azadirachta indica methanolic bark extract and their anti-proliferative activities against DU-145 human prostate cancer cells

Shedrack Reuben Kitimu
  • Shedrack Reuben Kitimu
  • Department of Molecular Biology and Biotechnology, Pan-African University, Institute of Basic Sciences, Technology and Innovation, P. O. Box 62000-00200, Nairobi, Kenya.
  • Google Scholar
Peter Kirira
  • Peter Kirira
  • Department of Physical Sciences, Mount Kenya University, General Kago Rd P. O. Box 342-01000 Thika, Kiambu, Kenya.
  • Google Scholar
Judith Sokei
  • Judith Sokei
  • Department of Molecular Biology and Biotechnology, Pan-African University, Institute of Basic Sciences, Technology and Innovation, P. O. Box 62000-00200, Nairobi, Kenya
  • Google Scholar
Dominic Ochwangi
  • Dominic Ochwangi
  • Department of Veterinary. Anatomy and Physiology, P.O Box 3709-00100, University of Nairobi, Kenya.
  • Google Scholar
Peter Mwitari
  • Peter Mwitari
  • Centre for Traditional Medicine and Drug Research, Kenya Medical Research Institute, P. O. Box 54840 00200, Off Mbagathi Road, Nairobi Kenya.
  • Google Scholar
Naomi Maina
  • Naomi Maina
  • Department of Molecular Biology and Biotechnology, Pan-African University, Institute of Basic Sciences, Technology and Innovation, P. O. Box 62000-00200, Nairobi, Kenya
  • Google Scholar


  •  Received: 27 October 2021
  •  Accepted: 17 January 2022
  •  Published: 28 February 2022

References

Abdelsalam NR, Abdel-Megeed A, Ali HM, Salem MZM, Al-Hayali MFA, Elshikh MS (2018). Genotoxicity effects of silver nanoparticles on wheat (Triticum aestivum L.) root tip cells. Ecotoxicology and Environmental Safety 155:76-85.
Crossref

 

Buttacavoli M, Albanese NN, Di Cara G, Alduina R, Faleri C, Gallo M, Pizzolanti G, Gallo G, Feo S, Baldi F (2018). Anticancer activity of biogenerated silver nanoparticles: an integrated proteomic investigation. Oncotarget 9(11):9685.
Crossref

 

Chen X, Jensen L (2016). Understanding the shape effect on the plasmonic response of small ligand coated nanoparticles. Journal of Optics 18(7): 074009.
Crossref

 

Gavamukulya Y, Maina EN, El-Shemy HA, Meroka AM, Kangogo GK, Magoma G, Wamunyokoli F (2021). Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis. Tumor Biology 43(1):37-55.
Crossref

 

Gomathi M, Prakasam A, Rajkumar PV (2019). Green synthesis, characterization and antibacterial activity of silver nanoparticles using Amorphophallus paeoniifolius leaf extract. Journal of Cluster Science 30(4):995-1001.
Crossref

 

Gudise V, Chowdhury B, Manjappa AS (2021). Antidiabetic and antihyperlipidemic effects of Argyreia pierreana and Matelea denticulata: Higher activity of the micellar nanoformulation over the crude extract. Journal of Traditional and Complementary Medicine 11(3):259-267.
Crossref

 

Gurunathan S, Park JH, Han JW, Kim JH (2015). Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy. International Journal of Nanomedicine 10:4203.
Crossref

 

Hareesh K, Williams JF, Dhole NA, Kodam KM, Bhoraskar VN, Dhole SD (2016). Bio-green synthesis of Ag-GO, Au-GO and Ag-Au-GO nanocomposites using Azadirachta indica: its application in SERS and cell viability. Materials Research Express 3(7):075010.
Crossref

 

Indrayanto G, Putra GS, Suhud F (2020). Validation of in-vitro bioassay methods: Application in herbal drug research. Profiles of Drug Substances, Excipients and Related Methodology 46:273-307.
Crossref

 

Ivanova N, Gugleva V, Dobreva M, Pehlivanov I, Stefanov S, Andonova V (2018). Silver nanoparticles as multi-functional drug delivery systems. In Nanomedicines. IntechOpen.
Crossref

 

Jain S, Mehata MS (2017). Medicinal plant leaf extract and pure flavonoid mediated green synthesis of silver nanoparticles and their enhanced antibacterial property. Scientific Reports 7(1):1-13.
Crossref

 

Kashif M, Kim D, Kim G (2018). In vitro antiproliferative and apoptosis inducing effect of a methanolic extract of Azadirachta indica oil on selected cancerous and noncancerous cell lines. Asian Pacific Journal of Tropical Medicine 11(10):555.
Crossref

 

Koch A, Tamez P, Pezzuto J, Soejarto D (2005). Evaluation of plants used for antimalarial treatment by the Maasai of Kenya. Journal of Ethnopharmacology 101(1-3):95-99.
Crossref

 

Mao BH, Tsai JC, Chen CW, Yan SJ, Wang YJ (2016). Mechanisms of silver nanoparticle-induced toxicity and important role of autophagy. Nanotoxicology 10(8):1021-1040.
Crossref

 

Martínez-Ballesta Mc, Gil-Izquierdo Á, García-Viguera C, Domínguez-Perles R (2018). Nanoparticles and controlled delivery for bioactive compounds: Outlining challenges for new "smart-foods" for health. Foods 7(5):72.
Crossref

 

Morhason-Bello IO, Odedina F, Rebbeck TR, Harford J, Dangou JM, Denny L, Adewole IF (2013). Challenges and opportunities in cancer control in Africa: a perspective from the African Organisation for Research and Training in Cancer. Lancet Oncology 14(4):e142-e151.
Crossref

 

Netala VR, Kotakadi VS, Domdi L, Gaddam SA, Bobbu P, Venkata SK, Ghosh SB, Tartte V (2016). Biogenic silver nanoparticles: efficient and effective antifungal agents. Applied Nanoscience 6(4):475-484.
Crossref

 

Nghilokwa E, Sokei J, Mwitari P, Maina N (2020). Sub-acute and chronic toxicity of silver nanoparticles synthesized by Azadirachta indica extract. African Journal of Biotechnology 19(6):320-331.
Crossref

 

Roy A, Bharadvaja N (2017). Medicinal plants in the management of cancer: a review. International Journal of Complementary and Alternative Medicine 9(2):291.
Crossref

 

Santana JS, de Carvalho Costa ÉK, Rodrigues PR, Correia PRC, Cruz RS, Druzian JI (2019). Morphological, barrier, and mechanical properties of cassava starch films reinforced with cellulose and starch nanoparticles. Journal of Applied Polymer Science 136(4):47001.
Crossref

 

Senapati S, Mahanta AK, Kumar S, Maiti P (2018). Controlled drug delivery vehicles for cancer treatment and their performance. Signal Transduction and Targeted Therapy 3(1):1-19.
Crossref

 

Siddiqui IA, Sanna V (2016). Impact of nanotechnology on the delivery of natural products for cancer prevention and therapy. Molecular Nutrition and Food Research 60(6):1330-1341.
Crossref

 

Sironmani TA (2016). Therapeutic potential of neem synthesized silver nanoparticles on human gastric cancer cells in vitro. World Journal of Nano Science and Engineering 6(2):90-110.
Crossref

 

Sokei J (2018). Azadirachta Indica Bark Extract Stabilized Silver Nanoparticles: Antiproliferative Activity, Acute Toxicity Study and Antitumour Activity. Pan African University Institute for Basic Sciences Technology and Innovation (PAUSTI).

 

Suh JH, Kotecha R, Chao ST, Ahluwalia MS, Sahgal A, Chang EL (2020). Current approaches to the management of brain metastases. Nature Reviews Clinical Oncology 17(5):279-299.
Crossref

 

Tavakol S, Hoveizi E, Kharrazi S, Tavakol B, Karimi S, Rezayat Sorkhabadi SM (2017). Organelles and chromatin fragmentation of human umbilical vein endothelial cell influence by the effects of zeta potential and size of silver nanoparticles in different manners. Artificial cells, Nanomedicine and Biotechnology 45(4):817-823.
Crossref

 

Velmurugan P, Cho M, Lim SS, Seo SK, Myung H, Bang KS, Sivakumar S, Cho KM, Oh BT (2015). Phytosynthesis of silver nanoparticles by Prunus yedoensis leaf extract and their antimicrobial activity. Materials Letters 138:272-275.
Crossref

 

Zhang XF, Shen W, Gurunathan S (2016). Silver nanoparticle-mediated cellular responses in various cell lines: an in vitro model. International Journal of Molecular Sciences 17(10):1603.
Crossref