African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Full Length Research Paper

Antidenaturation and antioxidative properties of phytochemical components from Spondias mombin

Afolabi C. Akinmoladun*
  • Afolabi C. Akinmoladun*
  • Phytomedicine, Drug Metabolism and Toxicology Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria.
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Olamide O. Crown
  • Olamide O. Crown
  • Phytomedicine, Drug Metabolism and Toxicology Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria.
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Olubukola B. Ojo
  • Olubukola B. Ojo
  • Phytomedicine, Drug Metabolism and Toxicology Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria.
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Tolulope M. Olaleye
  • Tolulope M. Olaleye
  • Phytomedicine, Drug Metabolism and Toxicology Unit, Department of Biochemistry, Federal University of Technology, Akure 340001, Nigeria.
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Ebenezer O. Farombi
  • Ebenezer O. Farombi
  • Drug Metabolism and Toxicology Unit, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.
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  •  Received: 12 April 2014
  •  Accepted: 26 May 2014
  •  Published: 31 May 2014

Abstract

The antidenaturation and antioxidant properties of Spondias mombin Linn (Anacardiaceae) methanol leaf extract (SMC) and fractions prepared from it were evaluated in this study. SMC and its fractions: ether (SME), saponin-rich (SMS) and flavonoid-rich (SMF) were phytochemically screened and evaluated for total antioxidant activity (TAA), ability to inhibit deoxyribose degradation (DEO), lipid peroxidation inhibitory activity (LPIA), 2,2 - diphenyl-1-picryl hydrazyl scavenging activity, ability to chelate ferrous ions and protein denaturation inhibitory activity (PRO). The antioxidant and antidenaturation activities were in the order SME > SMF > SMC > SMS. TAA strongly correlated with DEO, LPIA and PRO. The results indicate that S. mombin contains a diverse array of phytochemicals with potent antioxidant and bio-preservative properties which can serve as candidates for food preservation and drug development.

Key words: Spondias mombin, phytoconstituents, antioxidant activity, protein denaturation.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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