African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Full Length Research Paper

Serum lipids and oxidized low density lipoprotein levels in sickle cell disease: Assessment and pathobiological significance

Diatta Alassane
  • Diatta Alassane
  • Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, Pharmacy and Odontology, UCAD, Senegal
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Cissé Fatou
  • Cissé Fatou
  • Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, Pharmacy and Odontology, UCAD, Senegal
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Guèye Tall Fatou
  • Guèye Tall Fatou
  • Pharmaceutical Biochemistry Laboratory, Faculty of Medicine, Pharmacy and Odontology, UCAD, Senegal.
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Diallo Fatou
  • Diallo Fatou
  • Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, Pharmacy and Odontology, UCAD, Senegal
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Touré Fall Awa Oumar
  • Touré Fall Awa Oumar
  • Hematoly Laboratory, Aristide Le Dantec Hospital, Dakar, Senegal.
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Sarr Gaston Ndéné
  • Sarr Gaston Ndéné
  • Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, Pharmacy and Odontology, UCAD, Senegal
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Lopez Sall Philomène
  • Lopez Sall Philomène
  • Pharmaceutical Biochemistry Laboratory, Faculty of Medicine, Pharmacy and Odontology, UCAD, Senegal.
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Sall Niama Diop
  • Sall Niama Diop
  • Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, Pharmacy and Odontology, UCAD, Senegal
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Touré Méïssa
  • Touré Méïssa
  • Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, Pharmacy and Odontology, UCAD, Senegal
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  •  Accepted: 24 January 2014
  •  Published: 28 February 2014

Abstract

One hundred and eighteen (118) subjects aged 15 to 36 years divided into control subjects (AA n = 42), heterozygous sickle cell patients (AS n = 33) and homozygous sickle cell patients (SS n = 43) were investigated for a lipid profile including the measurement of oxidized low density lipoprotein (LDL) to assess the risk of early atherosclerosis in sickle cell disease. The results show that total, high density lipoprotein (HDL)  and LDL plasma cholesterol levels are significantly lower in the sickle cell patients than in control group (p < 0.05). In contrast, the triglyceride levels, the ratio of triglycerides to HDL-cholesterol and the oxidized LDL fraction are higher in patients (p < 0.05). These lipid abnormalities could represent a cardiovascular risk for sickle cell disease patients.

Key words: Atherosclerosis, dyslipidemia, oxidized low density lipoprotein (LDL), sickle cell disease.

Copyright © 2024 Author(s) retain the copyright of this article.

This article is published under the terms of the Creative Commons Attribution License 4.0

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