African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 399

Full Length Research Paper

Hepatoprotective effect of Cichorium intybus on CCl4-induced liver damage in rats

Sadeghi Heibatollah1*, Nikbakht Mohammad Reza2; Ghaitasi Izadpanah2 and Sabzali Sohailla3
  1Department of Biochemistry, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj –Iran and Herbal Medicine Research Center, Yasuj University of Medical Sciences, Yasuj –Iran. 2Department of Physiology and Pharmacology, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj –Iran and Herbal Medicine Research Center, Yasuj University of Medical Sciences, Yasuj –Iran. 3Imam Sajjad Hospital, Yasuj University of Medical Sciences, Yasuj, Iran.
Email: [email protected]

  •  Accepted: 11 April 2008
  •  Published: 30 June 2008

Abstract

 

The purpose of this study was to evaluate the hepatoprotective activity of hydroalcholic extract of Cichorium intybus (Cichorium intybus) using a carbon tetrachloride (CCl4) - induced liver injury in rats. The leaf extract at oral dosage of 200, 400 and 500 mg/kg exhibited significant (P<0.05) protective effect against CCl4 induced hepatoxocity. Level of serum markers such as aspartate aminotransferase (AST), alanine aminitransferase (ALT), alkaline phosphatase (ALP), total bilirubin (TB) were significantly increased in CCl4 treated rats. Simultaneously, C. intybus extract significantly suppressed mainly the increase in plasma activities of AST, ALT, ALP and TB concentration, which are considered as markers of liver functional state. The results of this study confirmed the hepatoprotective activity effect of the hydroalcholic extract of C. intybus.

 

Key words: Cichorium intybus, hepatoprotective activity, carbon tetrachloride, aspartate aminotransferase, alanine aminitransferase, alkaline phosphatase.