The antioxidant effect of methanolic extract of Pongamia pinnata was evaluated against lead acetate induced hepatic damage in male albino rats. Methanolic extract from the flowers of P. pinnata at a dose level of 150 mg/kg b.wt/day was administered orally daily once for 90 days. The substantially decreased enzymatic antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST) and non-enzymatic antioxidants like reduced glutathione (GSH), Vitamins C and E due to lead acetate treatment were restored towards normalization. Carvedilol at a dose level of 5 mg/kg b.wt/day was used as a standard reference also exhibited significant antioxidant activity against lead acetate induced hepatotoxicity. The results of this study strongly indicate that methanolic extract of P. pinnata has got a potent antioxidant action against lead acetate induced hepatic damage in rats.
Key words: Hepatoprotective, antioxidant enzymes, methanolic extract of Pongamia pinnata,lead acetate, carvedilol.
SOD, Superoxide dismutase; CAT, catalase; GPx, glutathione peroxidase; GR,glutathione reductase; GST, glutathione S-transferase; GSH, glutathione; CPCSEA, committee for the purpose of control and supervision on experimental animals; SPSS/PC, statistical package for social sciences, personal computer; DMRT, Duncan’s multiple range test; ROS,reactive oxygen species.
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