African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 384

Full Length Research Paper

Immunomodulatory effects of cement in exposed workers

Moses O. Akiibinu
  • Moses O. Akiibinu
  • Department of Chemistry and Biochemistry, Caleb University, Lagos, Nigeria.
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Taofeeq Oduola
  • Taofeeq Oduola
  • Department of Chemical Pathology, Faculty of Medical Laboratory Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
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Franklin Akinola
  • Franklin Akinola
  • Department of Medical Laboratory Sciences, Ladoke Akintola University, Ogbomoso, Osun State, Nigeria.
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  •  Received: 24 December 2018
  •  Accepted: 20 March 2019
  •  Published: 31 May 2019

Abstract

This study was conducted to assess the immunomodulatory potentials [immunoglobulin E (IgE), interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α)] of cement dust in individuals occupationally exposed to cement. Potentials of cement particles to modulate immune responses have not been documented in occupationally exposed Nigerians. Twenty-nine male cement loaders who had direct exposure to cement dust and gases for a period of 2 to 30 years in Elephant/Lafarge Cement Depot Ibadan, Nigeria, were recruited for this study. Another twenty apparently healthy individuals who had no interaction with cement served as controls. Plasma levels of IgE, IFN-γ and TNF-α were determined in them using enzyme linked immunosorbent assay (ELISA) methods. The results showed significantly (p<0.05) higher level of plasma IgE in cement loaders compared with controls. IFN-γ decreased significantly (p<0.05) in cement loaders, while TNF-α did not show significant (p>0.05) change in the cement loaders compared with controls. There was no significant (p>0.05) correlation between the IgE, IFN-γ, TNF-α and period of exposure in the cement loaders. Cement dust could evoke IgE production and possibly inhibit certain cell types secreting IFN-γ in occupationally exposed workers. Clinicians and researchers may need to rule out recent exposure to cement dust when working on type I hypersensitivity conditions.

 

Key words: Cement, allergen, Interferon-γ, necrotic factor-alpha.