African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 408

Full Length Research Paper

Profile of CA 15-3 and CEA during breast cancer chemotherapy at Ouagadougou, Burkina Faso

Fabienne Marie SOUDRE
  • Fabienne Marie SOUDRE
  • Unit of Training and Research in Health Sciences, University Joseph Ki-Zerbo, 03 P. O. Box 7021, Ouagadougou, Burkina Faso.
  • Google Scholar
Alice KIBA
  • Alice KIBA
  • Unit of Training and Research in Health Sciences, University Joseph Ki-Zerbo, 03 P. O. Box 7021, Ouagadougou, Burkina Faso.
  • Google Scholar
Arnaud KOURAOGO
  • Arnaud KOURAOGO
  • Unit of Training and Research in Health Sciences, University Joseph Ki-Zerbo, 03 P. O. Box 7021, Ouagadougou, Burkina Faso.
  • Google Scholar
Raoul KARFO
  • Raoul KARFO
  • Unit of Training and Research in Health Sciences, University Joseph Ki-Zerbo, 03 P. O. Box 7021, Ouagadougou, Burkina Faso.
  • Google Scholar
Aboubacar BAMBARA
  • Aboubacar BAMBARA
  • Unit of Training and Research in Health Sciences, University Joseph Ki-Zerbo, 03 P. O. Box 7021, Ouagadougou, Burkina Faso.
  • Google Scholar
Arsène KAGAMBEGA
  • Arsène KAGAMBEGA
  • University Hospital Centre of Bogodogo, 14 P. O. Box 371, Ouagadougou, Burkina Faso.
  • Google Scholar
Elie KABRE
  • Elie KABRE
  • Unit of Training and Research in Health Sciences, University Joseph Ki-Zerbo, 03 P. O. Box 7021, Ouagadougou, Burkina Faso.
  • Google Scholar
Jean SAKANDE
  • Jean SAKANDE
  • Unit of Training and Research in Health Sciences, University Joseph Ki-Zerbo, 03 P. O. Box 7021, Ouagadougou, Burkina Faso.
  • Google Scholar


  •  Received: 30 August 2021
  •  Accepted: 07 October 2021
  •  Published: 31 October 2021

Abstract

Biomarkers are considered as an innovative tool in the diagnosis and follow-up of breast cancer. The aim of the study was to assess the profile of circulating tumour markers CA 15-3 and CEA in patients under chemotherapy for breast cancer in Ouagadougou. This is a prospective cross-sectional study with a descriptive and analytical aims which was done from July to November 2020. Patients with histologically confirmed malignant breast tumour and under chemotherapy were included. Results revealed that the study was on thirty (30) female patients whose average age was 47.47 ± 2.10 years with a mean BMI of 27.29 ± 1.09 kg/m2. It was a non-specific type of infiltrating carcinoma with SBRm II grade in 90% of the patients. The mean CA 15-3 was 212.98 U/mL before chemotherapy and 165.75 U/mL after it. The CEA mean value was 3.13 ng/L before chemotherapy and 16.14 ng/L after it. Serum CA 15-3 was significantly associated with tumour site, SBRm grade, chemotherapy line and treatment response. Serum CEA level was significantly associated with tumour site and SBRm grade. Despite their lack of sensitivity, tumour markers, particularly CA 15-3 enabled assessment of the response to treatment in patients in this study.

 

Key words: Tumour markers, CA 15-3, CEA, breast cancer, chemotherapy.