African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 384

Full Length Research Paper

Effects of date fruit extract on paracetamol induced nephrotoxicity in wistar rats

Tijani Idris Ahmad Oseni
  • Tijani Idris Ahmad Oseni
  • Department of Family Medicine, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria
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Nurah Tijani Oseni
  • Nurah Tijani Oseni
  • Innovation and Technology Development Department, Nigerian Institute for oil Palm Research (NIFOR), Benin City, Nigeria
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Hauwa Tijani Oseni
  • Hauwa Tijani Oseni
  • Department of Biochemistry, University of Benin, Benin City, Nigeria
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Pauline Etuaje Eromon
  • Pauline Etuaje Eromon
  • Department of Family Medicine, Irrua Specialist Teaching Hospital, Irrua, Nigeria
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  •  Received: 03 February 2017
  •  Accepted: 04 April 2017
  •  Published: 30 April 2017

Abstract

This study was aimed to investigate the protective, ameliorative and preventive effects of aqueous Date fruit extract on paracetamol induced nephrotoxicity in wistar rats. A total of 30 male albino wistar rats were used for this study. Rats were randomly divided into five groups containing 6 animals each. Treatments were given daily for fourteen days. The animals in the control group (Group I) did not receive any treatment, while those in group 2 received paracetamol (2 g/kg/day). Group 3 were pretreated with aqueous date fruit extract (400 mg/kg/day) for a week before paracetamol administration. Rats in group 4 received paracetamol (2 g/kg/day) for a week before treatment with aqueous date palm extract (400 mg/kg). Group 5 was administered paracetamol (2 g/kg/day) in concurrent with 400 mg/kg aqueous date fruit extract. Exposure of rats with a nephrotoxic dose of paracetamol disturbed the kidney function tests; blood urea nitrogen (BUN) and serum creatinine (SC) levels increased significantly (P>0.05). The protective use of aqueous date fruit extract on paracetamol-induced nephrotoxicity resulted in a significant improvement in most evaluated parameters.

 

Key words: Date fruit, paracetamol, wistar rats, kidney.