African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 425

Full Length Research Paper

Detection of DNA damage in lead (Pb) exposed city traffic wardens in Pakistan

Ayesha Pervez
  • Ayesha Pervez
  • Department of Biochemistry, University of Health Sciences, Lahore, Pakistan.
  • Google Scholar
Fozan Ahmed
  • Fozan Ahmed
  • Department of Biochemistry, University of Health Sciences, Lahore, Pakistan.
  • Google Scholar
Nazish Mehmood Aisha
  • Nazish Mehmood Aisha
  • Department of Biochemistry, University of Health Sciences, Lahore, Pakistan.
  • Google Scholar
Salman Idrees
  • Salman Idrees
  • Department of Biochemistry, University of Health Sciences, Lahore, Pakistan.
  • Google Scholar
Muhammad Ikram Ullah
  • Muhammad Ikram Ullah
  • Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, Pakistan.
  • Google Scholar
Mohammad Zamir Ahmad
  • Mohammad Zamir Ahmad
  • Department of Biochemistry, University of Health Sciences, Lahore, Pakistan.
  • Google Scholar
Aftab Ahmed
  • Aftab Ahmed
  • School of Biological Sciences, University of the Punjab, Lahore, Pakistan.
  • Google Scholar
Muhammad Jawad Hassan*
  • Muhammad Jawad Hassan*
  • Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences (ASAB), National University of Sciences and Technology (NUST), Islamabad, Pakistan.
  • Google Scholar


  •  Received: 14 February 2015
  •  Published: 30 April 2015

References

Agha F, Sadaruddin A, Khatoon N (2005). Effect of environmental lead pollution on blood lead levels in traffic police constables in Islamabad, Pakistan. J. Pak. Med. Assoc. 55:410-413.
PMid:16304845
 
Best BP (2009). Nuclear DNA damage as a direct cause of aging. Rejuvenation. Res. 12:199-208.
Crossref
 
Binns HJ, Campbell C, Brown MJ (2007). Interpreting and managing blood lead levels of less than 10 microg/dL in children and reducing childhood exposure to lead: Ecommendations of the Centers for disease control and prevention advisory committee on childhood lead poisoning prevention. Pediatrics 120:e1285-e1298.
Crossref
 
Bohr VA (2002). DNA damage and its processing. relation to human disease. J. Inherit. Metab. Dis. 25:215-222.
Crossref
 
Browner WS, Kahn AJ, Ziv E, Reiner AP, Oshima J, Cawthon RM, Hsueh WC, Cummings SR (2004). The genetics of human longevity. Am. J. Med. 117:851-860.
Crossref
 
Chen Z, Lou J, Chen S, Zheng W, Wu W, Jin L, Deng H, He J (2006). Evaluating the genotoxic effects of workers exposed to lead using micronucleus assay, comet assay and TCR gene mutation test. Toxicology 23:219-226.
Crossref
 
Danadevi K, Rozati R, Saleha Banu B, Hanumanth Rao P, Grover P (2003). DNA damage in workers exposed to lead using comet assay. Toxicology 187:183-193.
Crossref
 
Fracasso ME, Perbellini L, Solda S, Talamini G, Franceschetti P (2002). Lead induced DNA strand breaks in lymphocytes of exposed workers: role of reactive oxygen species and protein kinase C. Mutat. Res. 515:159-169.
Crossref
 
Helsinki (WMA Declaration, 2013). Ethical Principles for Medical Research Involving Human Subjects. Available at URL: http://www.wma.net/en/30publications/10policies/b3/index.html. Retrieved on 20th March, 2015.
 
Johnson FM (1998). The genetic effects of environmental lead. Mutat. Res. 410:123-140.
Crossref
 
Khisroon M, Khan A, Naseem M, Ali N, Khan S, Rasheed SB (2015). Evaluation of DNA damage in lymphocytes of radiology personnel by comet assay. J Occup Health. 2015 Mar 6. [Epub ahead of print].
Crossref
 
Liao W, McNutt MA, Zhu WG (2009). The comet assay: a sensitive method for detecting DNA damage in individual cells. Methods 48:46-53.
Crossref
 
Mah LJ, El-Osta A and Karagiannis TC (2010) . Gamma H2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 4:679-686.
Crossref
 
Marnett LJ (2000). Oxyradicals and DNA damage. Carcinogenesis 21:361-370.
Crossref
 
Ogunsola OJ, Oluwole AF, Asubiojo OI, Durosinmi MA, Fatusi AO, Ruck W (1994). Environmental impact of vehicular traffic in Nigeria: health aspects. Sci. Total. Environ. 146-147:111-116.
Crossref
 
Olewinska E, Kasperczyk A, Kapka L, Kozlowska A, Pawlas N, Dobrakowski M, Birkner E, Kasperczyk S (2010). Level of DNA damage in lead-exposed workers. Ann. Agric. Environ. Med. 17:231-236.
 
Oyar O and KiÅŸlalioÄŸlu A (2012). How protective are lead aprons we use against ionizing radiations? Diagn. Interv. Radiol. 18(2):147-152.
 
Patrick L (2006). Lead toxicity part II: the role of free radical damage and the use of antioxidants in the pathology and treatment of lead toxicity. Altern. Med. Rev. 11:114-127.
 
Rosin A (2009). The Long-term Consequences of Exposure to Lead. Isr. Med. Assoc. J. 11:689-694.
 
Sadaruddin A, Agha F, Khatoon N, Sultana K (1995). Blood lead levels in young children in Chakshahzad, Islamabad. J. Pak. Med. Assoc. 45:215-218.
 
Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S (2004). Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73:39-85.
Crossref
 
Shotyk W, Le Roux G (2005). Biogeochemistry and cycling of lead. Met. Ions. Biol. Syst. 43:239-275.
Crossref
 
Subramanian R, Meares CF (1985). Photo-induced nicking of deoxyribonucleic acid by ruthenium(II)-bleomycin in the presence of air. Biochem. Biophys. Res. Commun. 133(3):1145-1151.
Crossrefh
 
Valverde M, Fortoul TI, Diaz-Barriga F, Mejia J, del Castillo ER (2002). Genotoxicity induced in CD-1 mice by inhaled lead: differential organ response. Mutagenesis. 17:55-61.
Crossref
 
Zaki A, El-Shazly M, Abdel-Fattah M, El-Said K, Curtale F (1998). Lead toxicity among working children and adolescents in Alexandria, Egypt. Eastern. Mediterranean. Health. J. 4(3):520-529.