African Journal of
Biochemistry Research

  • Abbreviation: Afr. J. Biochem. Res.
  • Language: English
  • ISSN: 1996-0778
  • DOI: 10.5897/AJBR
  • Start Year: 2007
  • Published Articles: 408

Full Length Research Paper

Inhibitory potential and antidiabetic activity of leaf extracts of Vitex doniana

Ani Onuabuchi Nnenna
  • Ani Onuabuchi Nnenna
  • Department of Applied Biochemistry, Faculty of Applied Natural Sciences, Enugu State University of Science and Technology, Enugu, Nigeria.
  • Google Scholar
Udedi Stanley Chidi
  • Udedi Stanley Chidi
  • Department of Applied Biochemistry, Faculty of Bio-Sciences, Nnamdi Azikiwe University, Awka, Anambra, Nigeria.
  • Google Scholar
Anajekwu Benedette Azuka
  • Anajekwu Benedette Azuka
  • Department of Applied Biochemistry, Faculty of Bio-Sciences, Nnamdi Azikiwe University, Awka, Anambra, Nigeria.
  • Google Scholar
Asogwa Kingsley Kelechi
  • Asogwa Kingsley Kelechi
  • Department of Applied Biochemistry, Faculty of Bio-Sciences, Nnamdi Azikiwe University, Awka, Anambra, Nigeria.
  • Google Scholar
Ekwealor Kenneth Udeh
  • Ekwealor Kenneth Udeh
  • Department of Botany, Faculty of Bio-Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria.
  • Google Scholar


  •  Received: 06 July 2020
  •  Published: 31 July 2020

References

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Alabo AA (1999). Utilization of black plum (Vitex doniana) fruit in jamproduction, in; Elemo, G.N (Ed). Proceedings of 23rd Annual Nigeria Institute of Food Science and Technology Conference, Raw materials and development council, Maitama, Abuja, Nigeria, pp. 270-272.

 
 

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Dauda BEN, Oyeleke SB, Jigam AA, Salihu SO, Balogun MM (2011). Phytochemical and In-vitro antibacterial investigation of Vitex doniana leaves stem Bark and Root bark Extracts. Australian Journal of Basic and Applied Sciences 5(7):523-528.

 
 

Ezekwesili CN, Ogbunugafor HA, Ezekwesili-Ofili JO (2012). Antidiabetic activity of aqueous extracts of Vitex doniana leaves and Cinchona bark in Alloxan-induced diabetic rats. International Journal of Tropical Diseases 2(4):290-300.

 
 

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Kwon YI, Apostolidis E, Shetty K (2007). Evaluation of pepper (Capsicum annuum) for management of diabetes and hypertension. Journal of Food Biochemistry 31(3):370-385.
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Mahomoodally MF, Subratty AH, Gurib-Fakim A, Choudary MI, Khan SN (2012). Traditional medicinal herbs and food plants have the potential to inhibit key carbohydrates hydrolyzing enzymes in vitro and reduce postprandial blood glucose peaks in vivo. Science World Journal, pp. 1- 9.
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McEwan R, Madivha RP, Djarova T, Oyedeji OA, Opoku AR (2010). Alpha- amylase inhibitor of amadumbe (Colocasia esculenta): isolation, purification and selectivity toward α-amylases from various sources. African Journal of Biochemistry Research 4(9):220-224.

 
 

Mogale AM, Lebelo LS, Thovhogi N, De Freitas AN, Shai L.J (2011). α-amylase and α-glucosidase inhibitory effects of sclerocarya birrea [(A. Rich.) Hochst.] subspecies caffra (Sond) Kokwaro (Anacardiaceae) stem-bark extracts." African Journal of Biotechnology 10(66):15033-15039.
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Nair SS, Kavrekar V, Mishra A (2013). In vitro studies on alphaamylase and alpha glucosidase inhibitory activities of selected plant extracts. European Journal of Experimental Biology 3(1):128-132.

 
 

Njoku OC, Airaodion AI, Awosanya O, Ekenjoku JA, Okoroukwu VN, Ogbuagu EO, Nwachukwu N, Igwe C (2019). Antidiabetic Potential of Alkaloid Extracts from Vitex doniana and Ficus thonningii Leaves on Alloxan-induced Diabetic Rats. International Research Journal of Gastroenterology and Hepatology 2(2):1-12.
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Obasi NA, Kalu MK, Chinyere GC, Otu Christian G, Nworie NC (2013). Effects of Aqueous and Methanolic Leaf Extracts of Vitex doniana on Lipid Profile and Liver Enzymes of Alloxan Induced Diabetic Albino Rats. Journal of Pharmaceutical Biology 6(5):37-43.
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Oboh G, Ademiluyi AO, Akinyemi AJ, Henle T, Saliu JA, Schwarzenbolz U (2012). Inhibitory effect of polyphenol-rich extracts of jute leaf (Corchorus olitorius) on key enzyme linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting) in vitro. Journal of Functional Foods 4(2):450-458. (2012). Inhibitory effect of polyphenol-rich extracts of jute leaf (Corchorusolitorius) on key enzyme linked to type 2 diabetes (α-amylase and α-glucosidase) and hypertension (angiotensin I converting) in vitro. J. Funct. Foods, 4: 450- 458.
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Patrice YAYD, Hubert KK, Siaka B, Parfait KEJ, Patrice KL (2015). Purification and biochemical characterization of a specific alpha-glucosidase from the digestive fluid of larvae of the palm weevil, Rhynchophoruspalmarum L. International Journal of Biosciences 7(1):74-85.
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Picot C, Subratty AH, Mahomoodally MF (2014). Inhibitory potential of five traditionally used native antidiabetic medicinal plants on α-amylase, α-glucosidase, glucose entrapment, and amylolysis kinetics in vitro. Advances in Pharmacological Sciences. Traditionally Used Native Antidiabetic Medicinal Plants on α-Amylase, α- Glucosidase, Glucose Entrapment, and Amylolysis Kinetics in vitro. Adv. Pharmacol. Sci. 14:1-7.
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Rauf A, Jehan N (2017). Natural Products as a Potential Enzyme Inhibitors from Medicinal Plants. Enzyme inhibitor and activators ed M Senturk (INTECH Pub). Chapter 7, p. 165.
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Reddy NV, Anarthe SJ, Raghavendra NM (2010). In vitro antioxidant and antidiabetic activity of Asystasia gangetica (Chinese Violet) Linn. (Acanthaceae). International Journal of Research in Pharmaceutical and Biomedical Sciences 1(2):72-75.

 
 

Sama K, Murugesan K, Sivaraj R (2012). In vitro alpha amylase and alpha glucosidase inhibition activity of crude ethanol extract of Cissus arnottiana. Asian Journal of Plant Science 2(4):550-553.

 
 

Sangeetha R, Vedashree N (2012). In virto α-amylase inhibitory activity of the leaves of Thespesia populnea. Pharmacology pp. 1-4.
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Shai LJ, Masoko P, Mokgotho MP, Magano SR, Mogale AM, Boaduo N, Eloff JN (2010). Yeast alpha glucosidase inhibitory and antioxidant activities of six medicinal plants collected in Phalaborwa, South Africa. South African Journal of Botany 10:1-6.
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Subramanian R, Asmawi AZ, Sadikun A (2008). In vitro α-glucosidase and α-amylase enzyme inhibitory effects of Andrographis paniculata extract Andrographolide. Acta Biochimica Polonica. 55(2):391-398.
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Sudha P, Zinjarde SS, Bhargava SY, Kumar AR (2011). Potent α-amylase inhibitory activity of Indian Ayuvedic medicinal plants. BMC Complementary and Alternative Medicine 11(1):5.
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Tundis R, Loizzo MR, Mernichini F (2010). Natural products as alpha amylase and alpha-glucosidase inhibitors and their hypoglycemic potential in the treatment of diabetes: An update. Mini Reviews in Medicinal Chemistry 10(4):315-331.
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