August 2018

The interplay between paraoxonase-1 and epigenetic changes in colorectal carcinoma

Colorectal cancer (CRC) is the third leading cause of cancer-related death. Colorectal mucosa has high levels of oxidative stress (OS) landmarks. OS has deleterious effect on cell structures as lipids, proteins and DNA. Markers of protein oxidation are named as advanced oxidation protein products (AOPPs) which have been considered as novel disease biomarkers. OS may also induce DNA damage which leads to mutation of...

Author(s): El-Tokhy Amira Kamel, Zin El-deen Doaa Hussein, Foda Abd allah Mahmoud, Moussa Gamal Ibrahim and Abo El-Noeman Saad El-Din Abd el-fatah