African Journal of
Cellular Pathology

OFFICIAL PUBLICATION OF THE SOCIETY FOR CELLULAR PATHOLOGY SCIENTISTS OF NIGERIA
  • Abbreviation: Afr. J. Cell. Path
  • Language: English
  • ISSN: 2449-0776
  • DOI: 10.5897/AJCPath
  • Start Year: 2013
  • Published Articles: 80

EFFECT OF PRENATAL ETHANOL EXPOSURE AND EXTRACT OF TAMARINDUS INDICA PULP ON THE CEREBRAL CORTEX OF WISTAR RATS

Usman IM
  • Usman IM
  • Department of Human Anatomy, Faculty of Medicine, Ahmadu Bello University, Zaria, Nigeria
  • Google Scholar
Buraimoh AA
  • Buraimoh AA
  • Department of Human Anatomy, Faculty of Medicine, Kaduna State University, Kaduna, Nigeria
  • Google Scholar
Ibegbu AO
  • Ibegbu AO
  • Department of Human Anatomy, Faculty of Medicine, Federal University Dutse, Jigawa, Nigeria
  • Google Scholar


  • Article Number - 284DB8D65704
  • Vol.7(1), pp. 1-5 , July 2016
  •  Received: 23 January 2016
  •  Accepted: 23 June 2016
  •  Published: 31 July 2016

Abstract

Aim: The aim of the study was to evaluate the effect of ethanolic pulp extract of Tamarindus indica (EPTI) on the cerebral cortex in prenatal ethanol exposure in Wistar rats.

Method: Twenty four pregnant rats were divided into 7 groups. The Control received 1ml of water, Groups 2 and 3 received 200mg/kg and 300mg/kg body weight (bw) of EPTI and Vitamin E respectively, Group 4 received 0.1ml of olive oil, Group 5 received 30%v/v of ethanol, Groups 6 and 7 received 30% v/v of ethanol and 200mg/kg bw of EPTI; and 30% v/v of ethanol and 300mg/kg bw of Vitamin E respectively. All administrations were via oral route, from prenatal day 7 to 14. At littering the brain tissues of the pups were collected for histological studies while some pups were used for Neurobehavioral studies.

Results: The result of elevated plus maze test showed significant increase in the time spent in the closed arm, rearing and grooming in Group 5 compared to the Control (p<0.05). Histological studies showed normal architecture in Groups 1, 2, 3 and 4, Group 5, 6 and 7 showed degenerative changes compared to the Control.

Conclusion: Treatments with EPTI and Vitamin E have shown some potential protective effects on the Cerebral cortex of Wistar rats during prenatal ethanol exposure.

Key words: Cerebrum, Ethanol, Prenatal, Tamarindus indica